Abstract
Appropriate complex-forming side-chains of peptides and proteins can bind cyclodextrins. We have characterized interactions of amino acids with cyclodextrins by electrospray ionization mass spectrometry. The stoichiometry of various α-cyclodextrin/protonated tryptophan complexes sampled from solution to the gas phase by ESI was revealed by taking advantage of the extended mass range and high mass resolution of a Fourier-transform ion cyclotron resonance instrument. Binding of β-cyclodextrin to recombinant human insulin has been demonstrated.
Original language | English |
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Pages (from-to) | 117-120 |
Number of pages | 4 |
Journal | Journal of Inclusion Phenomena and Molecular Recognition in Chemistry |
Volume | 25 |
Issue number | 1-3 |
DOIs | |
State | Published - 1 Jan 1996 |