Electrospray ionization mass spectrometry of cyclodextrin complexes of amino acids and peptides

Laszlo Prokai, R. Ramanathan, J. Nawrocki, J. Eyler

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Appropriate complex-forming side-chains of peptides and proteins can bind cyclodextrins. We have characterized interactions of amino acids with cyclodextrins by electrospray ionization mass spectrometry. The stoichiometry of various α-cyclodextrin/protonated tryptophan complexes sampled from solution to the gas phase by ESI was revealed by taking advantage of the extended mass range and high mass resolution of a Fourier-transform ion cyclotron resonance instrument. Binding of β-cyclodextrin to recombinant human insulin has been demonstrated.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume25
Issue number1-3
DOIs
StatePublished - 1 Jan 1996

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