Electrospray ionization mass spectrometry coupled with size‐exclusion chromatography

Laszlo Prokai, William J. Simonsick

Research output: Contribution to journalArticlepeer-review

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The coupling of electrospray ionization mass spectrometry with gel permeation chromatography (GPC) has been used for the separation of a commercial polydisperse mixture of octylphenoxypoly(ethoxy)ethanol. Stable electrospray conditions are obtained upon using, as GPC solvent, tetrahydrofuran containing 10−5−10−4M sodium salt which also provides for the formation of intact molecular ions through cationization. Selected‐ion chromatograms of sodiated species allow for the monitoring of the elution profiles of individual oligomers, and can be used for the calibration of the GPC.

Original languageEnglish
Pages (from-to)853-856
Number of pages4
JournalRapid Communications in Mass Spectrometry
Issue number9
StatePublished - Sep 1993


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