Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis

Michael W. Dunne, Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A. Krogstad, Mark Blatter, Richard Schwartz, Sergio L. Vargas, Paz Emparanza, Pilar Fernandez, Willis M. Gooch, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L. Blumer, Garth D. Ehrlich, Jean Chow

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Abstract

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

Original languageEnglish
Pages (from-to)2663-2665
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number8
DOIs
StatePublished - 1 Aug 2003

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    Dunne, M. W., Khurana, C., Mohs, A. A., Rodriguez, A., Arrieta, A., McLinn, S., Krogstad, J. A., Blatter, M., Schwartz, R., Vargas, S. L., Emparanza, P., Fernandez, P., Gooch, W. M., Aspin, M., Podgore, J., Roine, I., Blumer, J. L., Ehrlich, G. D., & Chow, J. (2003). Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis. Antimicrobial agents and chemotherapy, 47(8), 2663-2665. https://doi.org/10.1128/AAC.47.8.2663-2665.2003