Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

Vinita Batra; Zanobia Syed; Jennifer N. Gill; Malari A. Coburn; Patrick Adegboyega; John Digiovanni; J. Michael Mathis; Runhua Shi; John L. Clifford; Heather E. Kleiner-Hancock

doi:10.1186/1756-9966-31-57

Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

Vinita Batra, Zanobia Syed, Jennifer N. Gill, Malari A. Coburn, Patrick Adegboyega, John Digiovanni, J. Michael Mathis, Runhua Shi, John L. Clifford, Heather E. Kleiner-Hancock

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4 Scopus citations

Abstract

The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

Original language	English
Article number	57
Journal	Journal of Experimental and Clinical Cancer Research
Volume	31
Issue number	1
DOIs	https://doi.org/10.1186/1756-9966-31-57
State	Published - 2012

Keywords

Carcinogenesis
NF-κB
Squamous cell carcinoma
Stat3
TPA
Tropical ginger

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Batra, V., Syed, Z., Gill, J. N., Coburn, M. A., Adegboyega, P., Digiovanni, J., Mathis, J. M., Shi, R., Clifford, J. L., & Kleiner-Hancock, H. E. (2012). Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. Journal of Experimental and Clinical Cancer Research, 31(1), [57]. https://doi.org/10.1186/1756-9966-31-57

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title = "Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice",

abstract = "The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.",

keywords = "Carcinogenesis, NF-κB, Squamous cell carcinoma, Stat3, TPA, Tropical ginger",

author = "Vinita Batra and Zanobia Syed and Gill, {Jennifer N.} and Coburn, {Malari A.} and Patrick Adegboyega and John Digiovanni and Mathis, {J. Michael} and Runhua Shi and Clifford, {John L.} and Kleiner-Hancock, {Heather E.}",

note = "Funding Information: Grant from the Feist-Weiller Cancer Center, the Department of Pharmacology, Toxicology & Neuroscience. This research was also supported, in part, by National Cancer Institute grants 1K22CA102005-01A2 and 1R21CA149761-01A1(HKH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.",

year = "2012",

doi = "10.1186/1756-9966-31-57",

language = "English",

volume = "31",

journal = "Journal of Experimental and Clinical Cancer Research",

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AU - Batra, Vinita

AU - Syed, Zanobia

AU - Gill, Jennifer N.

AU - Coburn, Malari A.

AU - Adegboyega, Patrick

AU - Digiovanni, John

AU - Mathis, J. Michael

AU - Shi, Runhua

AU - Clifford, John L.

AU - Kleiner-Hancock, Heather E.

N1 - Funding Information: Grant from the Feist-Weiller Cancer Center, the Department of Pharmacology, Toxicology & Neuroscience. This research was also supported, in part, by National Cancer Institute grants 1K22CA102005-01A2 and 1R21CA149761-01A1(HKH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

PY - 2012

Y1 - 2012

N2 - The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

AB - The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

KW - Carcinogenesis

KW - NF-κB

KW - Squamous cell carcinoma

KW - Stat3

KW - TPA

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Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

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