Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

Vinita Batra, Zanobia Syed, Jennifer N. Gill, Malari A. Coburn, Patrick Adegboyega, John Digiovanni, J. Michael Mathis, Runhua Shi, John L. Clifford, Heather E. Kleiner-Hancock

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Abstract

The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

Original languageEnglish
Article number57
JournalJournal of Experimental and Clinical Cancer Research
Volume31
Issue number1
DOIs
StatePublished - 2012

Keywords

  • Carcinogenesis
  • NF-κB
  • Squamous cell carcinoma
  • Stat3
  • TPA
  • Tropical ginger

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    Batra, V., Syed, Z., Gill, J. N., Coburn, M. A., Adegboyega, P., Digiovanni, J., Mathis, J. M., Shi, R., Clifford, J. L., & Kleiner-Hancock, H. E. (2012). Effects of the tropical ginger compound,1-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. Journal of Experimental and Clinical Cancer Research, 31(1), [57]. https://doi.org/10.1186/1756-9966-31-57