Abstract
The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.
Original language | English |
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Article number | 57 |
Journal | Journal of Experimental and Clinical Cancer Research |
Volume | 31 |
Issue number | 1 |
DOIs | |
State | Published - 2012 |
Keywords
- Carcinogenesis
- NF-κB
- Squamous cell carcinoma
- Stat3
- TPA
- Tropical ginger