TY - JOUR
T1 - Effects of the group IIB metals (Cd, Zn and Hg) on the permeability of the crystalline lens of the toad (Bufo marinus)
AU - Bentley, P. J.
AU - Yorio, Thomas
N1 - Funding Information:
Acknowledgements--This work was supported by NIH Grant No. EY 01278. We are grateful to Miss Elizabeth Cruz for her expert technical assistance.
PY - 1976/10
Y1 - 1976/10
N2 - 1. 1. Cd, Zn, Hg and methyl mercury chloride (on anterior, not posterior) decrease the potential difference and short-circuit current across the lens of the toad. 2. 2. When translenticular Na transport was abolished, these metals were still effective. When Na was removed from the anterior, the effects of Cd and Zn were abolished, whereas Hg and CH3 Hg continued to act. Lenses in vitro accumulated Na and lost K in the presence of Cd and Hg but Zn or CH3Hg had no effect. 3. 3. O2 consumption in vitro was reduced by Zn, Hg and CH3Hg, but not Cd. In the absence of Na, Hg and CH3Hg still decreased O2 consumption indicating a general toxic effect. 4. 4. The group IIB metal ions alter the electrical parameters and permeability of the crystalline lens but they act in different ways which reflects their varied chemical properties.
AB - 1. 1. Cd, Zn, Hg and methyl mercury chloride (on anterior, not posterior) decrease the potential difference and short-circuit current across the lens of the toad. 2. 2. When translenticular Na transport was abolished, these metals were still effective. When Na was removed from the anterior, the effects of Cd and Zn were abolished, whereas Hg and CH3 Hg continued to act. Lenses in vitro accumulated Na and lost K in the presence of Cd and Hg but Zn or CH3Hg had no effect. 3. 3. O2 consumption in vitro was reduced by Zn, Hg and CH3Hg, but not Cd. In the absence of Na, Hg and CH3Hg still decreased O2 consumption indicating a general toxic effect. 4. 4. The group IIB metal ions alter the electrical parameters and permeability of the crystalline lens but they act in different ways which reflects their varied chemical properties.
UR - http://www.scopus.com/inward/record.url?scp=0017103086&partnerID=8YFLogxK
U2 - 10.1016/0306-3623(76)90020-3
DO - 10.1016/0306-3623(76)90020-3
M3 - Article
C2 - 824178
AN - SCOPUS:0017103086
VL - 7
SP - 355
EP - 360
JO - General Pharmacology
JF - General Pharmacology
SN - 0306-3623
IS - 5
ER -