Effects of schedules of reinforcement on brain catecholamine metabolism in the rat

L. H. Albert, M. Emmett-Oglesby, L. S. Seiden

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Rats were trained on a fixed ratio 5 (FR 5) for 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) fir 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) for 0.04 ml water reinforcer, a variable time 15 sec (VT 15 sec) for 0.01 ml water reinforcer, a variable time 30 sec (VT 30 sec) for 0.01 ml water, variable time 60 sec (VT 60 sec) for 0.01 ml water, or a variable time 60 sec (VT 60 sec) for 0.10 ml water. In all these schedules, the rate of NE metabolism varied with the number of water presentations but not with the number of responses or the volume of water. The rate of metabolism of DA was increased over control values in rats on the VT schedules but no significant differences could be found in DA metabolism among the rats performing on the various VT schedules or receiving various volumes.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number5
DOIs
StatePublished - May 1977

Keywords

  • Brain catecholamine metabolism
  • Nonadrenergic neuronal activity
  • Schedules of reinforcement
  • Tyrosine-hydroxylase inhibitor
  • α-Methyl-p-tyrosine

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