TY - JOUR
T1 - Effects of schedules of reinforcement on brain catecholamine metabolism in the rat
AU - Albert, L. H.
AU - Emmett-Oglesby, M.
AU - Seiden, L. S.
N1 - Funding Information:
The rate of NE metabolism was estimated either by the injection of tracer doses of 3 H-NE (Intraventricularly) or the injection of c~-methyl-p-tyrosine (IP). Male Sprague-Dawley rats (Holtzman) involved in radioactive tracer studies had indwelling cannula implanted in the right ventricle by the method of Hayden etal. \[9\]. Coordinates for placement of the cannula are given by Lewy and Seiden \[12\]. Rats were cannulated at 120 days of age. Rats were injected with 1.0uCi of a H-NE (New England Nuclear) in 10.0ul Merlis solution \[7\] via the cannula at the beginning of the experimental session. At the end of this session, rats were decapitated and brains dissected for cerebral cortices and brainstem-diencephalon by the method of Iversen and Glowinski \[ 10\]. The cortices were individually weighed and 1T his research was supported by U.S. Public Health Service National Institute of Mental Health Grant MH-11191 - 11. 2Supported by Training Grant USPHS 2 TO5 GM 01939-07 (MSTP). 3Supported by Research Career Development Award 5 KO2 MH 10562-08.
PY - 1977/5
Y1 - 1977/5
N2 - Rats were trained on a fixed ratio 5 (FR 5) for 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) fir 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) for 0.04 ml water reinforcer, a variable time 15 sec (VT 15 sec) for 0.01 ml water reinforcer, a variable time 30 sec (VT 30 sec) for 0.01 ml water, variable time 60 sec (VT 60 sec) for 0.01 ml water, or a variable time 60 sec (VT 60 sec) for 0.10 ml water. In all these schedules, the rate of NE metabolism varied with the number of water presentations but not with the number of responses or the volume of water. The rate of metabolism of DA was increased over control values in rats on the VT schedules but no significant differences could be found in DA metabolism among the rats performing on the various VT schedules or receiving various volumes.
AB - Rats were trained on a fixed ratio 5 (FR 5) for 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) fir 0.01 ml water reinforcer, a fixed ratio 20 (FR 20) for 0.04 ml water reinforcer, a variable time 15 sec (VT 15 sec) for 0.01 ml water reinforcer, a variable time 30 sec (VT 30 sec) for 0.01 ml water, variable time 60 sec (VT 60 sec) for 0.01 ml water, or a variable time 60 sec (VT 60 sec) for 0.10 ml water. In all these schedules, the rate of NE metabolism varied with the number of water presentations but not with the number of responses or the volume of water. The rate of metabolism of DA was increased over control values in rats on the VT schedules but no significant differences could be found in DA metabolism among the rats performing on the various VT schedules or receiving various volumes.
KW - Brain catecholamine metabolism
KW - Nonadrenergic neuronal activity
KW - Schedules of reinforcement
KW - Tyrosine-hydroxylase inhibitor
KW - α-Methyl-p-tyrosine
UR - http://www.scopus.com/inward/record.url?scp=0017686306&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(77)90105-8
DO - 10.1016/0091-3057(77)90105-8
M3 - Article
C2 - 896886
AN - SCOPUS:0017686306
SN - 0091-3057
VL - 6
SP - 481
EP - 486
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 5
ER -