Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice

I. Tayfun Uzbay; Cleatus J. Wallis; Harbans Lal; Michael J. Forster

doi:10.1016/S0166-4328(99)00129-1

Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice

I. Tayfun Uzbay, Cleatus J. Wallis, Harbans Lal, Michael J. Forster

Research output: Contribution to journal › Article › peer-review

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Abstract

Effects of MK-801 and ketamine, N-methyl-D-aspartate (NMDA) receptor blockers, on cocaine-stimulated locomotor activity were investigated in male Swiss-Webster mice. MK-801 (0.25, 0.5, 1.0 and 2.5 mg/kg), ketamine (10, 25 and 50 mg/kg) or saline was injected 20 min before cocaine (5, 10 and 20 mg/kg i.p.). Locomotor activity was measured for 30 min immediately following cocaine treatment. All doses of the drugs were also tested for ability to depress or stimulate locomotor activity in the naive (no cocaine-treated) mice. Cocaine produced a dose-dependent increase in locomotor activity that was blocked dose-dependently by MK-801 or ketamine. The blockade by MK-801 was more prominent than by ketamine. Our results may suggest that cocaine- induced locomotor stimulation in mice is modulated via NMDA receptor mediated mechanisms.

Original language	English
Pages (from-to)	57-61
Number of pages	5
Journal	Behavioural Brain Research
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/S0166-4328(99)00129-1
State	Published - Feb 2000

Keywords

Cocaine
Locomotor activity
Mice
NMDA receptors

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10.1016/S0166-4328(99)00129-1

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title = "Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice",

abstract = "Effects of MK-801 and ketamine, N-methyl-D-aspartate (NMDA) receptor blockers, on cocaine-stimulated locomotor activity were investigated in male Swiss-Webster mice. MK-801 (0.25, 0.5, 1.0 and 2.5 mg/kg), ketamine (10, 25 and 50 mg/kg) or saline was injected 20 min before cocaine (5, 10 and 20 mg/kg i.p.). Locomotor activity was measured for 30 min immediately following cocaine treatment. All doses of the drugs were also tested for ability to depress or stimulate locomotor activity in the naive (no cocaine-treated) mice. Cocaine produced a dose-dependent increase in locomotor activity that was blocked dose-dependently by MK-801 or ketamine. The blockade by MK-801 was more prominent than by ketamine. Our results may suggest that cocaine- induced locomotor stimulation in mice is modulated via NMDA receptor mediated mechanisms.",

keywords = "Cocaine, Locomotor activity, Mice, NMDA receptors",

author = "Uzbay, {I. Tayfun} and Wallis, {Cleatus J.} and Harbans Lal and Forster, {Michael J.}",

note = "Funding Information: This study was supported by the Scientific and Technical Research Council of Turkey (T{\"U}BİTAK-BAYG and NATO-B2) and the Substance Abuse Institute of North Texas. The authors would like to thank to Samantha A. Wild and Carla S. Elsken for their technical assistance during the study.",

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doi = "10.1016/S0166-4328(99)00129-1",

language = "English",

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AU - Uzbay, I. Tayfun

AU - Wallis, Cleatus J.

AU - Lal, Harbans

AU - Forster, Michael J.

N1 - Funding Information: This study was supported by the Scientific and Technical Research Council of Turkey (TÜBİTAK-BAYG and NATO-B2) and the Substance Abuse Institute of North Texas. The authors would like to thank to Samantha A. Wild and Carla S. Elsken for their technical assistance during the study.

PY - 2000/2

Y1 - 2000/2

N2 - Effects of MK-801 and ketamine, N-methyl-D-aspartate (NMDA) receptor blockers, on cocaine-stimulated locomotor activity were investigated in male Swiss-Webster mice. MK-801 (0.25, 0.5, 1.0 and 2.5 mg/kg), ketamine (10, 25 and 50 mg/kg) or saline was injected 20 min before cocaine (5, 10 and 20 mg/kg i.p.). Locomotor activity was measured for 30 min immediately following cocaine treatment. All doses of the drugs were also tested for ability to depress or stimulate locomotor activity in the naive (no cocaine-treated) mice. Cocaine produced a dose-dependent increase in locomotor activity that was blocked dose-dependently by MK-801 or ketamine. The blockade by MK-801 was more prominent than by ketamine. Our results may suggest that cocaine- induced locomotor stimulation in mice is modulated via NMDA receptor mediated mechanisms.

AB - Effects of MK-801 and ketamine, N-methyl-D-aspartate (NMDA) receptor blockers, on cocaine-stimulated locomotor activity were investigated in male Swiss-Webster mice. MK-801 (0.25, 0.5, 1.0 and 2.5 mg/kg), ketamine (10, 25 and 50 mg/kg) or saline was injected 20 min before cocaine (5, 10 and 20 mg/kg i.p.). Locomotor activity was measured for 30 min immediately following cocaine treatment. All doses of the drugs were also tested for ability to depress or stimulate locomotor activity in the naive (no cocaine-treated) mice. Cocaine produced a dose-dependent increase in locomotor activity that was blocked dose-dependently by MK-801 or ketamine. The blockade by MK-801 was more prominent than by ketamine. Our results may suggest that cocaine- induced locomotor stimulation in mice is modulated via NMDA receptor mediated mechanisms.

KW - Cocaine

KW - Locomotor activity

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KW - NMDA receptors

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JF - Behavioural Brain Research

IS - 1

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Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice

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Keywords

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