Abstract
In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.
Original language | English |
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Pages (from-to) | 188-194 |
Number of pages | 7 |
Journal | Pharmacology |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - 1979 |
Keywords
- 5-Hydroxytryptophan
- Benserazide
- Chlorimipramine
- Fever
- Fluoxetine
- Prostaglandin E
- Serotonin