Effects of increasing serotonergic receptor activity in brain on prostaglandin e1-induced fever in rabbits

M. T. Lin; I. H. Pang; S. I. Chern; Y. F. Chern

doi:10.1159/000137251

Effects of increasing serotonergic receptor activity in brain on prostaglandin e₁-induced fever in rabbits

M. T. Lin, I. H. Pang, S. I. Chern, Y. F. Chern

North Texas Eye Research Institute

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E₁. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E₁-induced fever.

Original language	English
Pages (from-to)	188-194
Number of pages	7
Journal	Pharmacology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1159/000137251
State	Published - 1979

Keywords

5-Hydroxytryptophan
Benserazide
Chlorimipramine
Fever
Fluoxetine
Prostaglandin E
Serotonin

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10.1159/000137251

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title = "Effects of increasing serotonergic receptor activity in brain on prostaglandin e1-induced fever in rabbits",

abstract = "In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.",

keywords = "5-Hydroxytryptophan, Benserazide, Chlorimipramine, Fever, Fluoxetine, Prostaglandin E, Serotonin",

author = "Lin, {M. T.} and Pang, {I. H.} and Chern, {S. I.} and Chern, {Y. F.}",

year = "1979",

doi = "10.1159/000137251",

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journal = "Pharmacology",

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T1 - Effects of increasing serotonergic receptor activity in brain on prostaglandin e1-induced fever in rabbits

AU - Lin, M. T.

AU - Pang, I. H.

AU - Chern, S. I.

AU - Chern, Y. F.

PY - 1979

Y1 - 1979

N2 - In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.

AB - In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.

KW - 5-Hydroxytryptophan

KW - Benserazide

KW - Chlorimipramine

KW - Fever

KW - Fluoxetine

KW - Prostaglandin E

KW - Serotonin

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SP - 188

EP - 194

JO - Pharmacology

JF - Pharmacology

IS - 4

ER -

Effects of increasing serotonergic receptor activity in brain on prostaglandin e₁-induced fever in rabbits

Abstract

Keywords

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