Effects of increasing serotonergic receptor activity in brain on prostaglandin e1-induced fever in rabbits

M. T. Lin, I. H. Pang, S. I. Chern, Y. F. Chern

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In rabbits, increasing serotonergic receptor activity or functional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate that brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalPharmacology
Volume18
Issue number4
DOIs
StatePublished - 1 Jan 1979

Keywords

  • 5-Hydroxytryptophan
  • Benserazide
  • Chlorimipramine
  • Fever
  • Fluoxetine
  • Prostaglandin E
  • Serotonin

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