TY - JOUR
T1 - [Effects of hsf1 genotype on the constitutive expression of alphaB-crystallin in mice myocardium].
AU - Liu, L.
AU - Zhang, Hong Hui
AU - Ding, Guo Xian
AU - Cheng, Yun Lin
AU - Yan, Liang Jun
AU - Benjamin, I. J.
PY - 2004/2
Y1 - 2004/2
N2 - Try to clarify the effects of HSF1 gene on the constitutively expressed alphaBC. To investigate the levels of constitutively expressed alphaB-Crystallin (alphaBC) in hsf1 knockout (hsf1 -/-) and hsf1 wild type (hsf1 +/+) mice myocardium by Western blot and immunohistochemistry. The alphaBC levels in hsf1 -/- and hsf1 +/+ were 68.42% +/- 4.16%, 100% +/- 7.58%, respectively (P < 0.05, cytosolic fraction), and 20.53% +/- 1.01%, 37.55% +/- 1.91%, respectively (P < 0.05, pellet fraction). The alphaBC signals decreased significantly in hsf1 -/- myocardium compared with hsf1 +/+ myocardium stained with fluorescence immunohistochemistry. hsf1 is the important, but not the only factor, which mediates the constitutively expressed alphaBC.
AB - Try to clarify the effects of HSF1 gene on the constitutively expressed alphaBC. To investigate the levels of constitutively expressed alphaB-Crystallin (alphaBC) in hsf1 knockout (hsf1 -/-) and hsf1 wild type (hsf1 +/+) mice myocardium by Western blot and immunohistochemistry. The alphaBC levels in hsf1 -/- and hsf1 +/+ were 68.42% +/- 4.16%, 100% +/- 7.58%, respectively (P < 0.05, cytosolic fraction), and 20.53% +/- 1.01%, 37.55% +/- 1.91%, respectively (P < 0.05, pellet fraction). The alphaBC signals decreased significantly in hsf1 -/- myocardium compared with hsf1 +/+ myocardium stained with fluorescence immunohistochemistry. hsf1 is the important, but not the only factor, which mediates the constitutively expressed alphaBC.
UR - http://www.scopus.com/inward/record.url?scp=84871946560&partnerID=8YFLogxK
M3 - Article
C2 - 21162300
AN - SCOPUS:84871946560
SN - 1000-6834
VL - 20
SP - 30
EP - 33
JO - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
JF - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
IS - 1
ER -