Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA

Khosrow Kashfi, Ladislav Dory, George A. Cook

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.

Original languageEnglish
Pages (from-to)1121-1126
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume177
Issue number3
DOIs
StatePublished - 28 Jun 1991

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