Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise

Shigehiko Ogoh, R. Matthew Brothers, Quinton Barnes, Wendy L. Eubank, Megan N. Hawkins, Sushmita Purkayastha, Albert Yurvati, Peter B. Raven

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

The purpose of this investigation was to examine whether the effect of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest was the same during exercise. Eight men (means ± SE: age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg) participated in the present study. Sixteen Torr of lower body negative pressure (LBNP) were applied to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak O2 uptake (104 ± 20 W). Subsequently, infusions of 25% human serum albumin solution were administered to increase CVP at rest and during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, the maximal gain (Gmax) of the carotid-vasomotor baroreflex function curve was measured using the neck pressure and neck suction technique. LBNP reduced CVP and increased the Gmax of the carotid-vasomotor baroreflex function curve at rest (+63 ± 25%, P = 0.006) and during exercise (+69 ± 19%, P = 0.002). In contrast to the LBNP, increases in CVP resulted in the Gmax of the carotid-vasomotor baroreflex function curve being decreased at rest -8 ± 4% and during exercise -18 ± 5% (P > 0.05). These findings indicate that the relationship between CVP and carotid-vasomotor baroreflex sensitivity was nonlinear at rest and during exercise and suggests a saturation load of the cardiopulmonary baroreceptors at which carotid-vasomotor baroreflex sensitivity remains unchanged.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Applied Physiology
Volume101
Issue number1
DOIs
StatePublished - 17 Jul 2006

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Central Venous Pressure
Baroreflex
Blood Volume
Lower Body Negative Pressure
Exercise
Neck
Pressoreceptors
Suction
Serum Albumin
Albumins
Leg
Arterial Pressure
Heart Rate
Pressure
Weights and Measures

Keywords

  • Arterial blood pressure
  • Cardiopulmonary baroreceptors
  • Central venous pressure

Cite this

Ogoh, S., Brothers, R. M., Barnes, Q., Eubank, W. L., Hawkins, M. N., Purkayastha, S., ... Raven, P. B. (2006). Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise. Journal of Applied Physiology, 101(1), 68-75. https://doi.org/10.1152/japplphysiol.01452.2005
Ogoh, Shigehiko ; Brothers, R. Matthew ; Barnes, Quinton ; Eubank, Wendy L. ; Hawkins, Megan N. ; Purkayastha, Sushmita ; Yurvati, Albert ; Raven, Peter B. / Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise. In: Journal of Applied Physiology. 2006 ; Vol. 101, No. 1. pp. 68-75.
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abstract = "The purpose of this investigation was to examine whether the effect of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest was the same during exercise. Eight men (means ± SE: age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg) participated in the present study. Sixteen Torr of lower body negative pressure (LBNP) were applied to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50{\%} peak O2 uptake (104 ± 20 W). Subsequently, infusions of 25{\%} human serum albumin solution were administered to increase CVP at rest and during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, the maximal gain (Gmax) of the carotid-vasomotor baroreflex function curve was measured using the neck pressure and neck suction technique. LBNP reduced CVP and increased the Gmax of the carotid-vasomotor baroreflex function curve at rest (+63 ± 25{\%}, P = 0.006) and during exercise (+69 ± 19{\%}, P = 0.002). In contrast to the LBNP, increases in CVP resulted in the Gmax of the carotid-vasomotor baroreflex function curve being decreased at rest -8 ± 4{\%} and during exercise -18 ± 5{\%} (P > 0.05). These findings indicate that the relationship between CVP and carotid-vasomotor baroreflex sensitivity was nonlinear at rest and during exercise and suggests a saturation load of the cardiopulmonary baroreceptors at which carotid-vasomotor baroreflex sensitivity remains unchanged.",
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Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise. / Ogoh, Shigehiko; Brothers, R. Matthew; Barnes, Quinton; Eubank, Wendy L.; Hawkins, Megan N.; Purkayastha, Sushmita; Yurvati, Albert; Raven, Peter B.

In: Journal of Applied Physiology, Vol. 101, No. 1, 17.07.2006, p. 68-75.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise

AU - Ogoh, Shigehiko

AU - Brothers, R. Matthew

AU - Barnes, Quinton

AU - Eubank, Wendy L.

AU - Hawkins, Megan N.

AU - Purkayastha, Sushmita

AU - Yurvati, Albert

AU - Raven, Peter B.

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N2 - The purpose of this investigation was to examine whether the effect of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest was the same during exercise. Eight men (means ± SE: age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg) participated in the present study. Sixteen Torr of lower body negative pressure (LBNP) were applied to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak O2 uptake (104 ± 20 W). Subsequently, infusions of 25% human serum albumin solution were administered to increase CVP at rest and during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, the maximal gain (Gmax) of the carotid-vasomotor baroreflex function curve was measured using the neck pressure and neck suction technique. LBNP reduced CVP and increased the Gmax of the carotid-vasomotor baroreflex function curve at rest (+63 ± 25%, P = 0.006) and during exercise (+69 ± 19%, P = 0.002). In contrast to the LBNP, increases in CVP resulted in the Gmax of the carotid-vasomotor baroreflex function curve being decreased at rest -8 ± 4% and during exercise -18 ± 5% (P > 0.05). These findings indicate that the relationship between CVP and carotid-vasomotor baroreflex sensitivity was nonlinear at rest and during exercise and suggests a saturation load of the cardiopulmonary baroreceptors at which carotid-vasomotor baroreflex sensitivity remains unchanged.

AB - The purpose of this investigation was to examine whether the effect of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest was the same during exercise. Eight men (means ± SE: age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg) participated in the present study. Sixteen Torr of lower body negative pressure (LBNP) were applied to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% peak O2 uptake (104 ± 20 W). Subsequently, infusions of 25% human serum albumin solution were administered to increase CVP at rest and during exercise. During all protocols, heart rate, arterial blood pressure, and CVP were recorded continuously. At each stage of LBNP or albumin infusion, the maximal gain (Gmax) of the carotid-vasomotor baroreflex function curve was measured using the neck pressure and neck suction technique. LBNP reduced CVP and increased the Gmax of the carotid-vasomotor baroreflex function curve at rest (+63 ± 25%, P = 0.006) and during exercise (+69 ± 19%, P = 0.002). In contrast to the LBNP, increases in CVP resulted in the Gmax of the carotid-vasomotor baroreflex function curve being decreased at rest -8 ± 4% and during exercise -18 ± 5% (P > 0.05). These findings indicate that the relationship between CVP and carotid-vasomotor baroreflex sensitivity was nonlinear at rest and during exercise and suggests a saturation load of the cardiopulmonary baroreceptors at which carotid-vasomotor baroreflex sensitivity remains unchanged.

KW - Arterial blood pressure

KW - Cardiopulmonary baroreceptors

KW - Central venous pressure

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U2 - 10.1152/japplphysiol.01452.2005

DO - 10.1152/japplphysiol.01452.2005

M3 - Article

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JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

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