Effects of carbamazepine on plasma haloperidol levels

Michael W. Jann, Larry Ereshefsky, Stephen R. Saklad, Donald R. Seidel, Chester M. Davis, Neil R. Burch, Charles L. Bowden

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Plasma haloperidol levels were monitored in three schizophrenic patients when carbamazepine was either added or discontinued. The percent decrease in plasma haloperidol levels due to concomitant carbamazepine therapy was between 59% and 61%. The effects of carbamazepine on plasma haloperidol levels were noted to occur in 2 to 3 weeks. Although no adverse effects occurred in the patients during therapy, careful monitoring of clinical symptoms and plasma haloperidol levels is recommended.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume5
Issue number2
DOIs
StatePublished - Apr 1985

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    Jann, M. W., Ereshefsky, L., Saklad, S. R., Seidel, D. R., Davis, C. M., Burch, N. R., & Bowden, C. L. (1985). Effects of carbamazepine on plasma haloperidol levels. Journal of Clinical Psychopharmacology, 5(2), 106-109. https://doi.org/10.1097/00004714-198504000-00010