Effects of aspirin and acetaminophen on fetal and placental growth in rats

W. C. Lubawy, R. J.Burriss Garrett

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Aqueous suspensions of aspirin or acetaminophen (125 and 250 mg/kg/day) were administered orally to pregnant Sprague‐Dawley rats on Days 8–19 of gestation. On gestation Day 20, each rat was sacrificed and the uterus was examined in situ. Each fetal—placental unit was resected and examined. Fetuses from rats given 125 or 250 mg/kg/day of aspirin were shorter and weighed less than those obtained from control rats. In animals receiving the higher dose of aspirin, the placentas were smaller and the number of fetal resorptions was increased. Acetaminophen (250 mg/kg/day) did not affect fetal length or weight or the incidence of resorptions. Acetaminophen interfered less with the normal growth of the rat fetus and placenta than did aspirin.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume66
Issue number1
DOIs
StatePublished - Jan 1977

Keywords

  • Acetaminophen—effects on fetal and placental growth, rats
  • Aspirin—effects on fetal and placental growth, rats
  • Fetal growth—effects of aspirin and acetaminophen, rats
  • Placental growth—effects of aspirin and acetaminophen, rats

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