Effect of therapeutic exercise on knee osteoarthritis after intraarticular injection of botulinum toxin type a, hyaluronate or saline: A randomized controlled trial

Xiao Bao, Jie Wen Tan, Michael Flyzik, Xian Cong Ma, Howe Liu, Hui Yu Liu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. Methods: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: Injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were conducted at baseline, and at the end of the 4th and 8th weeks. Results: At end of the 4th and 8th weeks, the scores on the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and visual analogue scale were higher in the control group. There were significant differences in Physical Component Summary-36 and Mental Component Summary-36 scores between the 3 groups (p < 0.05) at the end of the 4th and 8th weeks, but not between groups A (control) and C (hyaluronate) at the end of the 4th week. No changes were seen on magnetic resonance imaging and X-ray images of the affected knees after the intervention. Conclusion: Therapeutic exercise plus botulinum toxin type A or hyaluronate injection can significantly reduce pain and improve knee functioning. Botulinum toxin type A plus therapeutic exercise appears to be more effective.

Original languageEnglish
Pages (from-to)534-541
Number of pages8
JournalJournal of Rehabilitation Medicine
Volume50
Issue number6
DOIs
StatePublished - 1 Jan 2018

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Intra-Articular Injections
Type A Botulinum Toxins
Botulinum Toxins
Knee Osteoarthritis
Therapeutic Uses
Randomized Controlled Trials
Ontario
Osteoarthritis
Control Groups
Injections
Knee
Pain Measurement
Health Surveys
Visual Analog Scale
Therapeutics
Magnetic Resonance Imaging
X-Rays
Outcome Assessment (Health Care)
Pain
Surveys and Questionnaires

Keywords

  • Botulinum toxin type A
  • Dysfunction
  • Hyaluronate
  • Knee osteoarthritis
  • Therapeutic exercise

Cite this

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abstract = "Objective: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. Methods: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: Injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were conducted at baseline, and at the end of the 4th and 8th weeks. Results: At end of the 4th and 8th weeks, the scores on the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and visual analogue scale were higher in the control group. There were significant differences in Physical Component Summary-36 and Mental Component Summary-36 scores between the 3 groups (p < 0.05) at the end of the 4th and 8th weeks, but not between groups A (control) and C (hyaluronate) at the end of the 4th week. No changes were seen on magnetic resonance imaging and X-ray images of the affected knees after the intervention. Conclusion: Therapeutic exercise plus botulinum toxin type A or hyaluronate injection can significantly reduce pain and improve knee functioning. Botulinum toxin type A plus therapeutic exercise appears to be more effective.",
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Effect of therapeutic exercise on knee osteoarthritis after intraarticular injection of botulinum toxin type a, hyaluronate or saline : A randomized controlled trial. / Bao, Xiao; Tan, Jie Wen; Flyzik, Michael; Ma, Xian Cong; Liu, Howe; Liu, Hui Yu.

In: Journal of Rehabilitation Medicine, Vol. 50, No. 6, 01.01.2018, p. 534-541.

Research output: Contribution to journalArticle

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AU - Bao, Xiao

AU - Tan, Jie Wen

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AU - Ma, Xian Cong

AU - Liu, Howe

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AB - Objective: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. Methods: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: Injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were conducted at baseline, and at the end of the 4th and 8th weeks. Results: At end of the 4th and 8th weeks, the scores on the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and visual analogue scale were higher in the control group. There were significant differences in Physical Component Summary-36 and Mental Component Summary-36 scores between the 3 groups (p < 0.05) at the end of the 4th and 8th weeks, but not between groups A (control) and C (hyaluronate) at the end of the 4th week. No changes were seen on magnetic resonance imaging and X-ray images of the affected knees after the intervention. Conclusion: Therapeutic exercise plus botulinum toxin type A or hyaluronate injection can significantly reduce pain and improve knee functioning. Botulinum toxin type A plus therapeutic exercise appears to be more effective.

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