Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials

Sivakumar Ramachandran, Marc B. Taraban, Jill Trewhella, Ignacy Gryczynski, Zygmunt Gryczynski, Yihua Bruce Yu

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations, including dynamic rheometry, small-angle X-ray scattering (SAXS), and fluorescence spectroscopy, were used to investigate hydrogelation at the bulk, fiber, and molecular levels, respectively. It has been found that temperature has a significant effect on the structure and mechanical properties of peptide-based biomaterials. Oligopeptide fibers assembled at 25 °C are formed faster and are two times thicker, and the resulting material is mechanically seven times stronger than that assembled at 5 °C.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalBiomacromolecules
Volume11
Issue number6
DOIs
StatePublished - 14 Jul 2010

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