TY - JOUR
T1 - Effect of sleep restriction on orthostatic cardiovascular control in humans
AU - Muenter, N. K.
AU - Watenpaugh, D. E.
AU - Wasmund, W. L.
AU - Wasmund, S. L.
AU - Maxwell, S. A.
AU - Smith, M. L.
PY - 2000/3
Y1 - 2000/3
N2 - We hypothesized that sleep restriction (4 consecutive nights, 4 h sleep/night) attenuates orthostatic tolerance. The effect of sleep restriction on cardiovascular responses to simulated orthostasis, arterial baroreflex gain, and heart rate variability was evaluated in 10 healthy volunteers. Arterial baroreflex gain was determined from heart rate responses to nitroprusside-phenylephrine injections, and orthostatic tolerance was tested via lower body negative pressure (LBNP). A Finapres device measured finger arterial pressure. No difference in baroreflex function, heart rate variability, or LBNP tolerance was observed with sleep restriction (P > 0.3). Systolic pressure was greater at -60 mmHg LBNP after sleep restriction than before sleep restriction (110 ± 6 and 124 ± 3 mmHg before and after sleep restriction, respectively, P = 0.038), whereas heart rate decreased (108 ± 8 and 99 ± 8 beats/min before and after sleep restriction, respectively, P = 0.028). These data demonstrate that sleep restriction produces subtle changes in cardiovascular responses to simulated orthostasis, but these changes do not compromise orthostatic tolerance.
AB - We hypothesized that sleep restriction (4 consecutive nights, 4 h sleep/night) attenuates orthostatic tolerance. The effect of sleep restriction on cardiovascular responses to simulated orthostasis, arterial baroreflex gain, and heart rate variability was evaluated in 10 healthy volunteers. Arterial baroreflex gain was determined from heart rate responses to nitroprusside-phenylephrine injections, and orthostatic tolerance was tested via lower body negative pressure (LBNP). A Finapres device measured finger arterial pressure. No difference in baroreflex function, heart rate variability, or LBNP tolerance was observed with sleep restriction (P > 0.3). Systolic pressure was greater at -60 mmHg LBNP after sleep restriction than before sleep restriction (110 ± 6 and 124 ± 3 mmHg before and after sleep restriction, respectively, P = 0.038), whereas heart rate decreased (108 ± 8 and 99 ± 8 beats/min before and after sleep restriction, respectively, P = 0.028). These data demonstrate that sleep restriction produces subtle changes in cardiovascular responses to simulated orthostasis, but these changes do not compromise orthostatic tolerance.
KW - Arterial baroreflex
KW - Blood pressure
KW - Heart rate variability
KW - Lower body negative pressure
KW - Partial sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=0034066524&partnerID=8YFLogxK
U2 - 10.1152/jappl.2000.88.3.966
DO - 10.1152/jappl.2000.88.3.966
M3 - Article
C2 - 10710392
AN - SCOPUS:0034066524
SN - 8750-7587
VL - 88
SP - 966
EP - 972
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 3
ER -