Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

Henryk F. Urbanski, Krystina G. Sorwell, Laszlo Prokai, Steven G. Kohama

Research output: Contribution to journalArticle

Abstract

The hippocampus of rhesus macaques expresses genes that encode key enzymes involved in the intracrine conversion of dehydroepiandrosterone (DHEA) to estradiol. Therefore, it is plausible that supplementary DHEA may enhance hippocampal estradiol concentrations and help to compensate for the marked postmenopausal attenuation of circulating estrogen levels. To test this hypothesis, we used LC-MS/MS to measure estradiol and estrone concentrations in the serum and hippocampus of young and old perimenopausal female rhesus macaques, as well as old perimenopausal females that received daily DHEA (5 mg) oral supplementation for 1 week. Despite lower concentrations of these estrogens in the serum of the older animals, their concentrations in the hippocampus did not show any obvious differences due to age or to DHEA supplementation. The results suggest that de novo estrogen synthesis in the brain may compensate for the perimenopausal loss of estrogens in the circulation even without supplemental DHEA.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalNeurobiology of Aging
Volume55
DOIs
StatePublished - 1 Jul 2017

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Dehydroepiandrosterone
Macaca mulatta
Estrogens
Estradiol
Hippocampus
Serum
Estrone
Brain
Enzymes
Genes

Keywords

  • Dehydroepiandrosterone
  • Estradiol
  • Estrone
  • Hippocampus
  • Menopause

Cite this

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abstract = "The hippocampus of rhesus macaques expresses genes that encode key enzymes involved in the intracrine conversion of dehydroepiandrosterone (DHEA) to estradiol. Therefore, it is plausible that supplementary DHEA may enhance hippocampal estradiol concentrations and help to compensate for the marked postmenopausal attenuation of circulating estrogen levels. To test this hypothesis, we used LC-MS/MS to measure estradiol and estrone concentrations in the serum and hippocampus of young and old perimenopausal female rhesus macaques, as well as old perimenopausal females that received daily DHEA (5 mg) oral supplementation for 1 week. Despite lower concentrations of these estrogens in the serum of the older animals, their concentrations in the hippocampus did not show any obvious differences due to age or to DHEA supplementation. The results suggest that de novo estrogen synthesis in the brain may compensate for the perimenopausal loss of estrogens in the circulation even without supplemental DHEA.",
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Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques. / Urbanski, Henryk F.; Sorwell, Krystina G.; Prokai, Laszlo; Kohama, Steven G.

In: Neurobiology of Aging, Vol. 55, 01.07.2017, p. 172-174.

Research output: Contribution to journalArticle

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AU - Kohama, Steven G.

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