Effect of polymer concentration on the morphology and in-vitro insulin release of PCL microspheres

Anindita Mukerjee, Amalendu Prakash Ranjan, Vikas Pruthi

Research output: Contribution to specialist publicationArticle


Advances in immunotherapy, chemotherapy and delivery of antibiotics, hormones, enzymes, antibodies, antigens and other therapeutic or diagnostic agents have made the preparation and use of synthetic biodegradable polymers an area of increasing interest. These technological advancements have brought many new innovative drug delivery systems into commercial circulation. Polymer based microsphere delivery is one such innovative approach. In our study we chose poly-ε-caprolactone as our polymer of choice as it is a novel biodegradable and biocompatible polymer. The present study investigates the effect of polymer concentration on the entrapment, particle size, morphology and in-vitro release studies of insulin loaded poly-ε-caprolactone microspheres. Our studies showed that the polymer concentration indeed affects the characteristics of the microspheres and the release of the drug from the drug loaded microspheres.

Original languageEnglish
Number of pages8
Specialist publicationResearch Journal of Biotechnology
StatePublished - Nov 2008


  • Double emulsion solvent evaporation
  • Drug delivery systems
  • Microspheres
  • Poly-ε-caprolactone
  • Scanning electron microscopy


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