Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids

E. Sherwood Brown, Alan Frol, Leonardo Bobadilla, Vicki Allene Nejtek, Dana C. Perantie, Harminder Dhillon

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Mood changes, cognitive deficits, and psychosis have been reported during corticosteroid therapy. However, minimal data are available on the treatment of these side effects. This pilot study examined the effect of 12 weeks of open- label lamotrigine treatment (dose: mean = 340 mg/day, SD = 65) on mood and cognition in five patients receiving prescription corticosteroids continuously for at least 6 months before study entry. The participants showed significant improvement in cognition with lamotrigine. Two subjects who met criteria for a current major depressive episode at baseline had baseline-to-exit reductions in scores on the Hamilton Depression Rating Scale of more than 20 points. These pilot data suggest that lamotrigine may be associated with improved mood and performance on cognitive tasks in steroid-treated patients. Larger controlled trials are needed to confirm these preliminary findings.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalPsychosomatics
Volume44
Issue number3
DOIs
StatePublished - 1 Jan 2003

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Cognition
Adrenal Cortex Hormones
Psychotic Disorders
Prescriptions
Therapeutics
Steroids
Depression
lamotrigine
Mood
Dose
Rating Scales
Prescription
Exit
Therapy
Controlled
Psychosis

Cite this

Brown, E. Sherwood ; Frol, Alan ; Bobadilla, Leonardo ; Nejtek, Vicki Allene ; Perantie, Dana C. ; Dhillon, Harminder. / Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids. In: Psychosomatics. 2003 ; Vol. 44, No. 3. pp. 204-208.
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Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids. / Brown, E. Sherwood; Frol, Alan; Bobadilla, Leonardo; Nejtek, Vicki Allene; Perantie, Dana C.; Dhillon, Harminder.

In: Psychosomatics, Vol. 44, No. 3, 01.01.2003, p. 204-208.

Research output: Contribution to journalArticle

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