Effect of ketamine on thermoregulation in rats

M. T. Lin, C. F. Chen, Iok-Hou Pang

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26 Citations (Scopus)

Abstract

Intraperitoneal administration of ketamine produced dose-dependent hypothermia at the ambient temperature (T(a)) of both 8 and 23°C in unanesthetized rats. At a T(a) of 8° C, the hypothermia was brought about solely by a decrease in metabolic heat production. There were no changes in either the tail skin temperature (T(tail)) or the sole skin temperature (T(sole)). At a T(a) of 23° C, the hypothermia was due to an increase in T(tail), an increase in T(sole), and a decrease in metabolic heat production. However, at a T(a) of 31° C, there were no changes in rectal temperature in response to ketamine application, since neither heat production nor skin temperatures (e.g., T(tail) and (T(Sole)) was affected by ketamine at this T(a). The data indicate that the effect of the drug treatment may be to decrease heat production and (or) increase heat loss.

Original languageEnglish
Pages (from-to)963-967
Number of pages5
JournalCanadian Journal of Physiology and Pharmacology
Volume56
Issue number6
DOIs
StatePublished - 1 Jan 1978

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Body Temperature Regulation
Ketamine
Thermogenesis
Temperature
Skin Temperature
Tail
Hypothermia
Hot Temperature
Pharmaceutical Preparations

Cite this

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title = "Effect of ketamine on thermoregulation in rats",
abstract = "Intraperitoneal administration of ketamine produced dose-dependent hypothermia at the ambient temperature (T(a)) of both 8 and 23°C in unanesthetized rats. At a T(a) of 8° C, the hypothermia was brought about solely by a decrease in metabolic heat production. There were no changes in either the tail skin temperature (T(tail)) or the sole skin temperature (T(sole)). At a T(a) of 23° C, the hypothermia was due to an increase in T(tail), an increase in T(sole), and a decrease in metabolic heat production. However, at a T(a) of 31° C, there were no changes in rectal temperature in response to ketamine application, since neither heat production nor skin temperatures (e.g., T(tail) and (T(Sole)) was affected by ketamine at this T(a). The data indicate that the effect of the drug treatment may be to decrease heat production and (or) increase heat loss.",
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Effect of ketamine on thermoregulation in rats. / Lin, M. T.; Chen, C. F.; Pang, Iok-Hou.

In: Canadian Journal of Physiology and Pharmacology, Vol. 56, No. 6, 01.01.1978, p. 963-967.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of ketamine on thermoregulation in rats

AU - Lin, M. T.

AU - Chen, C. F.

AU - Pang, Iok-Hou

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N2 - Intraperitoneal administration of ketamine produced dose-dependent hypothermia at the ambient temperature (T(a)) of both 8 and 23°C in unanesthetized rats. At a T(a) of 8° C, the hypothermia was brought about solely by a decrease in metabolic heat production. There were no changes in either the tail skin temperature (T(tail)) or the sole skin temperature (T(sole)). At a T(a) of 23° C, the hypothermia was due to an increase in T(tail), an increase in T(sole), and a decrease in metabolic heat production. However, at a T(a) of 31° C, there were no changes in rectal temperature in response to ketamine application, since neither heat production nor skin temperatures (e.g., T(tail) and (T(Sole)) was affected by ketamine at this T(a). The data indicate that the effect of the drug treatment may be to decrease heat production and (or) increase heat loss.

AB - Intraperitoneal administration of ketamine produced dose-dependent hypothermia at the ambient temperature (T(a)) of both 8 and 23°C in unanesthetized rats. At a T(a) of 8° C, the hypothermia was brought about solely by a decrease in metabolic heat production. There were no changes in either the tail skin temperature (T(tail)) or the sole skin temperature (T(sole)). At a T(a) of 23° C, the hypothermia was due to an increase in T(tail), an increase in T(sole), and a decrease in metabolic heat production. However, at a T(a) of 31° C, there were no changes in rectal temperature in response to ketamine application, since neither heat production nor skin temperatures (e.g., T(tail) and (T(Sole)) was affected by ketamine at this T(a). The data indicate that the effect of the drug treatment may be to decrease heat production and (or) increase heat loss.

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