Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation

Xiangrong Shi, Seth Rehrer, Parna Prajapati, Scott T. Stoll, Russell G. Gamber, H. Fred Downey

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Context: The use of cranial osteopathic manipulative medicine (OMM) to alter cerebral tissue oxygen saturation could play a role in the maintenance of cerebral homeostasis. Objective: To examine the effects of cranial OMM on cerebral tissue oxygen saturation (S CTO 2) and cardiac autonomic function in healthy adults. Methods:Cranial OMM augmentation and suppression techniques and sham therapy were randomly applied to healthy adults. During cranial OMM and sham therapy, S CTO 2of the prefrontal cortex was determined bilaterally by using nearinfrared spectroscopy. Heart rate, blood pressure, and systemic arterial blood oxygen saturation (SaO 2) were also measured. Power spectral analysis was applied to continuous 4-minute R-R intervals. Measurements were made during 2-minute baseline periods, during 4-minute applications of the techniques, and during 5-minute recovery periods. Results: Twenty-one adults (age range, 23-32 y) participated in the present study. Differences in mean baseline measurements for the augmentation technique, suppression technique, and sham therapy were not statistically significant for heart rate, blood pressure, SaO 2, left S CTO 2, or right S CTO 2. During the suppression technique, there was a statistically significant decrease in both left (slope [standard deviation]= -0.33 [0.08] %/min, R 2=0.85, P=.026) and right (slope [standard deviation]=-0.37 [0.06] %/min, R 2=0.94, P=.007) S CTO 2with increased cranial OMM time. However, neither the augmentation technique nor the sham therapy had a statistically significant effect on S CTO 2. Decreases in normalized low-frequency power of R-R interval variability and enhancements of its high-frequency power were statistically significant (P=.05) during cranial OMM and sham therapy, indicating a decrease in cardiac sympathetic influence and an enhanced parasympathetic modulation. Conclusion: The cranial OMM suppression technique effectively and progressively reduced S CTO 2in both prefrontal lobes with the treatment time.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalJournal of the American Osteopathic Association
Volume111
Issue number12
StatePublished - 1 Dec 2011

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Osteopathic Medicine
Oxygen
Arterial Pressure
Heart Rate
Therapeutics
Prefrontal Cortex
Spectrum Analysis
Homeostasis
Maintenance
Blood Pressure

Cite this

Shi, X., Rehrer, S., Prajapati, P., Stoll, S. T., Gamber, R. G., & Fred Downey, H. (2011). Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. Journal of the American Osteopathic Association, 111(12), 660-666.
Shi, Xiangrong ; Rehrer, Seth ; Prajapati, Parna ; Stoll, Scott T. ; Gamber, Russell G. ; Fred Downey, H. / Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. In: Journal of the American Osteopathic Association. 2011 ; Vol. 111, No. 12. pp. 660-666.
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abstract = "Context: The use of cranial osteopathic manipulative medicine (OMM) to alter cerebral tissue oxygen saturation could play a role in the maintenance of cerebral homeostasis. Objective: To examine the effects of cranial OMM on cerebral tissue oxygen saturation (S CTO 2) and cardiac autonomic function in healthy adults. Methods:Cranial OMM augmentation and suppression techniques and sham therapy were randomly applied to healthy adults. During cranial OMM and sham therapy, S CTO 2of the prefrontal cortex was determined bilaterally by using nearinfrared spectroscopy. Heart rate, blood pressure, and systemic arterial blood oxygen saturation (SaO 2) were also measured. Power spectral analysis was applied to continuous 4-minute R-R intervals. Measurements were made during 2-minute baseline periods, during 4-minute applications of the techniques, and during 5-minute recovery periods. Results: Twenty-one adults (age range, 23-32 y) participated in the present study. Differences in mean baseline measurements for the augmentation technique, suppression technique, and sham therapy were not statistically significant for heart rate, blood pressure, SaO 2, left S CTO 2, or right S CTO 2. During the suppression technique, there was a statistically significant decrease in both left (slope [standard deviation]= -0.33 [0.08] {\%}/min, R 2=0.85, P=.026) and right (slope [standard deviation]=-0.37 [0.06] {\%}/min, R 2=0.94, P=.007) S CTO 2with increased cranial OMM time. However, neither the augmentation technique nor the sham therapy had a statistically significant effect on S CTO 2. Decreases in normalized low-frequency power of R-R interval variability and enhancements of its high-frequency power were statistically significant (P=.05) during cranial OMM and sham therapy, indicating a decrease in cardiac sympathetic influence and an enhanced parasympathetic modulation. Conclusion: The cranial OMM suppression technique effectively and progressively reduced S CTO 2in both prefrontal lobes with the treatment time.",
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Shi, X, Rehrer, S, Prajapati, P, Stoll, ST, Gamber, RG & Fred Downey, H 2011, 'Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation', Journal of the American Osteopathic Association, vol. 111, no. 12, pp. 660-666.

Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. / Shi, Xiangrong; Rehrer, Seth; Prajapati, Parna; Stoll, Scott T.; Gamber, Russell G.; Fred Downey, H.

In: Journal of the American Osteopathic Association, Vol. 111, No. 12, 01.12.2011, p. 660-666.

Research output: Contribution to journalArticleResearchpeer-review

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Shi X, Rehrer S, Prajapati P, Stoll ST, Gamber RG, Fred Downey H. Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. Journal of the American Osteopathic Association. 2011 Dec 1;111(12):660-666.