Effect of cadmium on epithelial membranes

L. N. Fleisher, T. Yorio, P. J. Bentley

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalToxicology and Applied Pharmacology
Volume33
Issue number2
DOIs
StatePublished - Aug 1975

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