Abstract
Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.
| Original language | English |
|---|---|
| Pages (from-to) | 384-387 |
| Number of pages | 4 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Jan 1975 |
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Effect of cadmium on epithelial membranes. / Fleisher, L. N.; Yorio, Thomas; Bentley, P. J.
In: Toxicology and Applied Pharmacology, Vol. 33, No. 2, 01.01.1975, p. 384-387.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of cadmium on epithelial membranes
AU - Fleisher, L. N.
AU - Yorio, Thomas
AU - Bentley, P. J.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.
AB - Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.
UR - http://www.scopus.com/inward/record.url?scp=0016834547&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(75)90106-4
DO - 10.1016/0041-008X(75)90106-4
M3 - Article
C2 - 809863
AN - SCOPUS:0016834547
VL - 33
SP - 384
EP - 387
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -