@article{656921f8e5e34ae7abe99405ad6d2487,
title = "Effect of cadmium on epithelial membranes",
abstract = "Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.",
author = "Fleisher, {L. N.} and T. Yorio and Bentley, {P. J.}",
note = "Funding Information: The ventral skin from frogs (Ranapippiens) was used to make diaphragm preparations in divided chambers bathed on each side with Ringer{\textquoteright}s solution (Ussing and Zerahn, 1951). Toad (Bufo marinus) urinary bladder preparations were made as sacs( Bentley, 1958). Due to variability in the different batches of toads, animals from the same shipment were used for each group of experiments. The electrical potential difference (PD), short-circuit current (SCC), and electrical resistance were measured between the two sides of each membrane. The PD was measured (with a voltmeter, Keithley 200b) through a pair of calomel cells which were connected to each side of the membrane by saturated KCI-agar bridges. The SCC was applied from an external battery through 1 Supported by NSF Grant GB-28543X (PJB), a CUNY Research Assistantship (LNF), and a Mount Sinai Graduate School Fellowship (TY).",
year = "1975",
month = aug,
doi = "10.1016/0041-008X(75)90106-4",
language = "English",
volume = "33",
pages = "384--387",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",
}