Effect of cadmium on epithelial membranes

L. N. Fleisher; T. Yorio; P. J. Bentley

doi:10.1016/0041-008X(75)90106-4

Effect of cadmium on epithelial membranes

L. N. Fleisher, T. Yorio, P. J. Bentley

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Abstract

Cd²⁺ (10^-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd²⁺ (10^-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10^-3 m and 10^-4 m at the mucosa or 10^-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.

Original language	English
Pages (from-to)	384-387
Number of pages	4
Journal	Toxicology and Applied Pharmacology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0041-008X(75)90106-4
Publication status	Published - Aug 1975

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Fleisher, L. N., Yorio, T., & Bentley, P. J. (1975). Effect of cadmium on epithelial membranes. Toxicology and Applied Pharmacology, 33(2), 384-387. https://doi.org/10.1016/0041-008X(75)90106-4

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abstract = "Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.",

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N2 - Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.

AB - Cd2+ (10-3m) on the external side of the frog skin, increased the electrical potential difference (PD), short-circuit current (SCC), and resistance across this membrane. The effect was irreversible. Cd2+ (10-3 m) on the serosal side of the toad urinary bladder inhibited the SCC, but this was increased by 10-3 m and 10-4 m at the mucosa or 10-4 m at the serosa. The increases in SCC were inhibited by amiloride, indicating the effect was due to a stimulation of active transmural sodium transport. The increased resistance seen in the frog skin may reflect a decreased permeability to chloride. These results indicate that cadmium can influence active ion transport and the permeability of epithelial membranes.

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10.1016/0041-008X(75)90106-4

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