Effect of aging on neuroglobin expression in rodent brain

Yunjuan Sun, Kunlin Jin, Xiao Ou Mao, Lin Xie, Alyson Peel, Jocelyn T. Childs, Anna Logvinova, Xiaojuan Wang, David A. Greenberg

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalNeurobiology of Aging
Volume26
Issue number2
DOIs
StatePublished - 1 Feb 2005

Keywords

  • Aging
  • Hypoxia
  • Ischemia
  • Neuroglobin

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    Sun, Y., Jin, K., Mao, X. O., Xie, L., Peel, A., Childs, J. T., Logvinova, A., Wang, X., & Greenberg, D. A. (2005). Effect of aging on neuroglobin expression in rodent brain. Neurobiology of Aging, 26(2), 275-278. https://doi.org/10.1016/j.neurobiolaging.2004.03.006