Effect of aging on neuroglobin expression in rodent brain

Yunjuan Sun; Kunlin Jin; Xiao Ou Mao; Lin Xie; Alyson Peel; Jocelyn T. Childs; Anna Logvinova; Xiaojuan Wang; David A. Greenberg

doi:10.1016/j.neurobiolaging.2004.03.006

Effect of aging on neuroglobin expression in rodent brain

Yunjuan Sun, Kunlin Jin, Xiao Ou Mao, Lin Xie, Alyson Peel, Jocelyn T. Childs, Anna Logvinova, Xiaojuan Wang, David A. Greenberg

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Neuroglobin (Ngb), a recently discovered O₂-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders.

Original language	English
Pages (from-to)	275-278
Number of pages	4
Journal	Neurobiology of Aging
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2004.03.006
State	Published - Feb 2005

Keywords

Aging
Hypoxia
Ischemia
Neuroglobin

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10.1016/j.neurobiolaging.2004.03.006

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title = "Effect of aging on neuroglobin expression in rodent brain",

abstract = "Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders.",

keywords = "Aging, Hypoxia, Ischemia, Neuroglobin",

author = "Yunjuan Sun and Kunlin Jin and Mao, {Xiao Ou} and Lin Xie and Alyson Peel and Childs, {Jocelyn T.} and Anna Logvinova and Xiaojuan Wang and Greenberg, {David A.}",

note = "Funding Information: Supported by USPHS grant R01 NS35965. ",

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T1 - Effect of aging on neuroglobin expression in rodent brain

AU - Sun, Yunjuan

AU - Jin, Kunlin

AU - Mao, Xiao Ou

AU - Xie, Lin

AU - Peel, Alyson

AU - Childs, Jocelyn T.

AU - Logvinova, Anna

AU - Wang, Xiaojuan

AU - Greenberg, David A.

N1 - Funding Information: Supported by USPHS grant R01 NS35965.

PY - 2005/2

Y1 - 2005/2

N2 - Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders.

AB - Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders.

KW - Aging

KW - Hypoxia

KW - Ischemia

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Effect of aging on neuroglobin expression in rodent brain

Abstract

Keywords

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