Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun; Lin Xie; Xiaoou Mao; Justin Hill; David A. Greenberg; Kunlin Jin

doi:10.3233/RNN-2012-120254

Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun, Lin Xie, Xiaoou Mao, Justin Hill, David A. Greenberg, Kunlin Jin

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

Original language	English
Pages (from-to)	491-495
Number of pages	5
Journal	Restorative Neurology and Neuroscience
Volume	30
Issue number	6
DOIs	https://doi.org/10.3233/RNN-2012-120254
State	Published - 2012

Keywords

Stroke
ischemia
rat
recovery

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10.3233/RNN-2012-120254

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abstract = "Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.",

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T1 - Effect of a contralateral lesion on neurological recovery from stroke in rats

AU - Sun, Fen

AU - Xie, Lin

AU - Mao, Xiaoou

AU - Hill, Justin

AU - Greenberg, David A.

AU - Jin, Kunlin

PY - 2012

Y1 - 2012

N2 - Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

AB - Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

KW - Stroke

KW - ischemia

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Effect of a contralateral lesion on neurological recovery from stroke in rats

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