Edoxaban: How Does the Newest Agent Fit into the DOAC Landscape?

Caitlin Marie Gibson, Shannon W. Finks

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Edoxaban is the most recently approved factor Xa inhibitor within the class of direct oral anticoagulants (DOACs). Like other DOACs, edoxaban was approved by the US Food and Drug Administration for treatment of venous thromboembolism and prevention of stroke in patients with nonvalvular atrial fibrillation. Similar to other DOACs, edoxaban has fewer drug–drug interactions than warfarin and does not require routine laboratory monitoring. Unlike other DOACs, edoxaban has yet to be approved for secondary or postoperative venous thromboembolism thromboprophylaxis. Currently no antidote for edoxaban is available. To optimally prescribe agents in the DOAC class, it is critical that providers 1) understand how the agents compare; and 2) identify specific settings in which one agent may be preferred over another.

Original languageEnglish
Pages (from-to)900-906
Number of pages7
JournalAmerican Journal of Medicine
Volume130
Issue number8
DOIs
StatePublished - 1 Aug 2017

Fingerprint

Anticoagulants
Venous Thromboembolism
Antidotes
Warfarin
United States Food and Drug Administration
Atrial Fibrillation
Stroke
edoxaban
Therapeutics

Keywords

  • Anticoagulation
  • Atrial fibrillation
  • Direct oral anticoagulant
  • Edoxaban
  • Factor Xa inhibitors
  • Venous thromboembolism

Cite this

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Edoxaban : How Does the Newest Agent Fit into the DOAC Landscape? / Gibson, Caitlin Marie; Finks, Shannon W.

In: American Journal of Medicine, Vol. 130, No. 8, 01.08.2017, p. 900-906.

Research output: Contribution to journalReview article

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T2 - How Does the Newest Agent Fit into the DOAC Landscape?

AU - Gibson, Caitlin Marie

AU - Finks, Shannon W.

PY - 2017/8/1

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AB - Edoxaban is the most recently approved factor Xa inhibitor within the class of direct oral anticoagulants (DOACs). Like other DOACs, edoxaban was approved by the US Food and Drug Administration for treatment of venous thromboembolism and prevention of stroke in patients with nonvalvular atrial fibrillation. Similar to other DOACs, edoxaban has fewer drug–drug interactions than warfarin and does not require routine laboratory monitoring. Unlike other DOACs, edoxaban has yet to be approved for secondary or postoperative venous thromboembolism thromboprophylaxis. Currently no antidote for edoxaban is available. To optimally prescribe agents in the DOAC class, it is critical that providers 1) understand how the agents compare; and 2) identify specific settings in which one agent may be preferred over another.

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KW - Atrial fibrillation

KW - Direct oral anticoagulant

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KW - Factor Xa inhibitors

KW - Venous thromboembolism

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