TY - JOUR
T1 - Early detection of cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging
AU - Shepherd, Danielle L.
AU - Nichols, Cody E.
AU - Croston, Tara L.
AU - McLaughlin, Sarah L.
AU - Petrone, Ashley B.
AU - Lewis, Sara E.
AU - Thapa, Dharendra
AU - Long, Dustin M.
AU - Dick, Gregory M.
AU - Hollander, John M.
N1 - Funding Information:
The authors would like to thank the WVU Animal Models and Imaging Facility for all of the echocardiographic images, which has been supported by the Mary Babb Randolph Cancer Center and NIH grants P20 RR016440, P30 GM103488 and S10 RR026378. This work was supported by NIH DP2DK083095 (J.M.H.), NIH R56 HL128485 (J.M.H.), NIH T32HL090610 (T.L.C., D.L.S.), AHA - 14PRE19890020 (D.L.S.), AHA - 13PRE16850066 (C.E.N.), DGE - 1144676 (C.E.N.) and WVU CTSI ( NIH U54GM104942 ).
Publisher Copyright:
© 2015.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Enhanced sensitivity in echocardiographic analyses may allow for early detection of changes in cardiac function beyond the detection limits of conventional echocardiographic analyses, particularly in a small animal model. The goal of this study was to compare conventional echocardiographic measurements and speckle-tracking based strain imaging analyses in a small animal model of type 1 diabetes mellitus. Conventional analyses revealed differences in ejection fraction, fractional shortening, cardiac output, and stroke volume in diabetic animals relative to controls at 6-weeks post-diabetic onset. In contrast, when assessing short- and long-axis speckle-tracking based strain analyses, diabetic mice showed changes in average systolic radial strain, radial strain rate, radial displacement, and radial velocity, as well as decreased circumferential and longitudinal strain rate, as early as 1-week post-diabetic onset and persisting throughout the diabetic study. Further, we performed regional analyses for the LV and found that the free wall region was affected in both the short- and long-axis when assessing radial dimension parameters. These changes began 1-week post-diabetic onset and remained throughout the progression of the disease. These findings demonstrate the use of speckle-tracking based strain as an approach to elucidate cardiac dysfunction from a global perspective, identifying left ventricular cardiac regions affected during the progression of type 1 diabetes mellitus earlier than contractile changes detected by conventional echocardiographic measurements.
AB - Enhanced sensitivity in echocardiographic analyses may allow for early detection of changes in cardiac function beyond the detection limits of conventional echocardiographic analyses, particularly in a small animal model. The goal of this study was to compare conventional echocardiographic measurements and speckle-tracking based strain imaging analyses in a small animal model of type 1 diabetes mellitus. Conventional analyses revealed differences in ejection fraction, fractional shortening, cardiac output, and stroke volume in diabetic animals relative to controls at 6-weeks post-diabetic onset. In contrast, when assessing short- and long-axis speckle-tracking based strain analyses, diabetic mice showed changes in average systolic radial strain, radial strain rate, radial displacement, and radial velocity, as well as decreased circumferential and longitudinal strain rate, as early as 1-week post-diabetic onset and persisting throughout the diabetic study. Further, we performed regional analyses for the LV and found that the free wall region was affected in both the short- and long-axis when assessing radial dimension parameters. These changes began 1-week post-diabetic onset and remained throughout the progression of the disease. These findings demonstrate the use of speckle-tracking based strain as an approach to elucidate cardiac dysfunction from a global perspective, identifying left ventricular cardiac regions affected during the progression of type 1 diabetes mellitus earlier than contractile changes detected by conventional echocardiographic measurements.
KW - Cardiac function
KW - Diabetes mellitus
KW - Diabetic cardiomyopathy
KW - Echocardiography
KW - Speckle-tracking imaging
KW - Strain analysis
UR - http://www.scopus.com/inward/record.url?scp=84949843998&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2015.12.001
DO - 10.1016/j.yjmcc.2015.12.001
M3 - Article
C2 - 26654913
AN - SCOPUS:84949843998
SN - 0022-2828
VL - 90
SP - 74
EP - 83
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
ER -