Drug Effects on Intraocular Pressure and Vascular Flow in the Bovine Perfused Eye Using Radiolabelled Microspheres

J. C. Millar, W. S. Wilson, R. D. Carr, R. G. Humphries

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A novel technique is described in which the effect of the β-adrenoceptor antagonists timolol and carteolol, and the vasodilators sodium nitroprusside (SNP) and verapamil on intraocular pressure (IOP) and the distribution of ocular flow in the bovine arterially perfused eye is investigated using radiolabelled microspheres. At maximum IOP-reducing dose timolol was found to significantly reduce perfusion in the choroid and, at higher dose, it was found to significantly reduce perfusion in the iris. By contrast, a maximal IOP-reducing dose of carteolol markedly reduced perfusion in the iris, ciliary body and choroid. Vasoconstriction induced by carteolol was not inhibited by the α-antagonist phentolamine. Against a background of vascular tone induced by noradrenaline, SNP and verapamil were found to significantly increase perfusion in the iris, ciliary body and choroid. The effects of these drugs upon the vasculature of the bovine perfused eye are varied and complex and may not bear a direct relationship to their ocular hypotensive effect.

Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalJournal of Ocular Pharmacology and Therapeutics
Volume11
Issue number1
DOIs
StatePublished - 1 Jan 1995

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Carteolol
Intraocular Pressure
Microspheres
Blood Vessels
Choroid
Iris
Perfusion
Timolol
Ciliary Body
Nitroprusside
Verapamil
Pharmaceutical Preparations
Phentolamine
Vasoconstriction
Vasodilator Agents
Adrenergic Receptors
Norepinephrine

Cite this

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abstract = "A novel technique is described in which the effect of the β-adrenoceptor antagonists timolol and carteolol, and the vasodilators sodium nitroprusside (SNP) and verapamil on intraocular pressure (IOP) and the distribution of ocular flow in the bovine arterially perfused eye is investigated using radiolabelled microspheres. At maximum IOP-reducing dose timolol was found to significantly reduce perfusion in the choroid and, at higher dose, it was found to significantly reduce perfusion in the iris. By contrast, a maximal IOP-reducing dose of carteolol markedly reduced perfusion in the iris, ciliary body and choroid. Vasoconstriction induced by carteolol was not inhibited by the α-antagonist phentolamine. Against a background of vascular tone induced by noradrenaline, SNP and verapamil were found to significantly increase perfusion in the iris, ciliary body and choroid. The effects of these drugs upon the vasculature of the bovine perfused eye are varied and complex and may not bear a direct relationship to their ocular hypotensive effect.",
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Drug Effects on Intraocular Pressure and Vascular Flow in the Bovine Perfused Eye Using Radiolabelled Microspheres. / Millar, J. C.; Wilson, W. S.; Carr, R. D.; Humphries, R. G.

In: Journal of Ocular Pharmacology and Therapeutics, Vol. 11, No. 1, 01.01.1995, p. 11-23.

Research output: Contribution to journalArticle

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