Dose dependence and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

Ran Liu; Xiaofei Wang; Qing Liu; Shao Hua Yang; James W. Simpkins

doi:10.1016/j.neulet.2007.01.074

Dose dependence and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

Ran Liu, Xiaofei Wang, Qing Liu, Shao Hua Yang, James W. Simpkins

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E₂) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E₂ at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E₂ extended the therapeutic window to 6 h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

Original language	English
Pages (from-to)	237-241
Number of pages	5
Journal	Neuroscience letters
Volume	415
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2007.01.074
State	Published - 30 Mar 2007

Keywords

Cerebral-ischemia
Estrogen
Neuroprotection

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10.1016/j.neulet.2007.01.074

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abstract = "The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E2 at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E2 extended the therapeutic window to 6 h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.",

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AU - Simpkins, James W.

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AB - The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E2 at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E2 extended the therapeutic window to 6 h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

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Dose dependence and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

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Keywords

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