Dose dependence and therapeutic window for the neuroprotective effects of 17β-estradiol when administered after cerebral ischemia

Ran Liu, Xiaofei Wang, Qing Liu, Shao Hua Yang, James W. Simpkins

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E2 at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E2 extended the therapeutic window to 6 h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalNeuroscience letters
Volume415
Issue number3
DOIs
StatePublished - 30 Mar 2007

Keywords

  • Cerebral-ischemia
  • Estrogen
  • Neuroprotection

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