TY - JOUR
T1 - Dopamine homeostasis
T2 - Brain functional connectivity in reward deficiency syndrome
AU - Febo, Marcelo
AU - Blum, Kenneth
AU - Badgaiyan, Rajendra D.
AU - Baron, David
AU - Thanos, Panayotis K.
AU - Colon-Perez, Luis M.
AU - Demotrovics, Zsolt
AU - Gold, Mark S.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Reward deficiency syndrome (RDS) was first proposed by Kenneth Blum in 1995 to provide a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic dopamine function. Genetic, molecular, and neuronal alterations in key components of this circuitry contribute to a reward deficit state that can drive drug-seeking, consumption, and relapse. Among the dysfunctions observed in RDS are dysregulated resting state networks, which recently have been assessed in detail in chronic drug users by, positron emission tomography, functional magnetic resonance imaging, and functional connectivity analysis. A growing number of studies are helping to determine the putative roles of dopamine and glutamatergic neurotransmission in the regulation of activity in resting state networks, particularly in brain reward circuitry affected in drug use disorders. Indeed, we hypothesize in the present review that loss of homeostasis of these systems may lead to 'unbalanced' functional networks that might be both cause and outcome of disrupted synaptic communication between cortical and subcortical systems essential for controlling reward, emotional control, sensation seeking, and chronic drug use.
AB - Reward deficiency syndrome (RDS) was first proposed by Kenneth Blum in 1995 to provide a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic dopamine function. Genetic, molecular, and neuronal alterations in key components of this circuitry contribute to a reward deficit state that can drive drug-seeking, consumption, and relapse. Among the dysfunctions observed in RDS are dysregulated resting state networks, which recently have been assessed in detail in chronic drug users by, positron emission tomography, functional magnetic resonance imaging, and functional connectivity analysis. A growing number of studies are helping to determine the putative roles of dopamine and glutamatergic neurotransmission in the regulation of activity in resting state networks, particularly in brain reward circuitry affected in drug use disorders. Indeed, we hypothesize in the present review that loss of homeostasis of these systems may lead to 'unbalanced' functional networks that might be both cause and outcome of disrupted synaptic communication between cortical and subcortical systems essential for controlling reward, emotional control, sensation seeking, and chronic drug use.
KW - Addiction
KW - Dopamine
KW - DRD2 Gene
KW - Functional magnetic resonance imaging
KW - Genetics
KW - Glutamate
KW - RDS
KW - Resting state functional connectivity
KW - Reward deficiency syndrome
KW - Stress
KW - Taq1 A1 allele
UR - http://www.scopus.com/inward/record.url?scp=85039996983&partnerID=8YFLogxK
U2 - 10.2741/4509
DO - 10.2741/4509
M3 - Review article
C2 - 27814639
AN - SCOPUS:85039996983
SN - 1093-9946
VL - 22
SP - 669
EP - 691
JO - Frontiers in Bioscience
JF - Frontiers in Bioscience
IS - 4
ER -