DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas

Martha J. Felini, Andrew F. Olshan, Jane C. Schroeder, Kari E. North, Susan E. Carozza, Karl T. Kelsey, Mei Liu, Terri Rice, John K. Wiencke, Margaret R. Wrensch

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71).

Original languageEnglish
Pages (from-to)55-58
Number of pages4
Issue number1-2
StatePublished - Nov 2007


  • Brain tumors
  • Case-control
  • DNA repair polymorphisms
  • Gliomas
  • MGMT
  • XRCC1


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