DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas

Martha J. Felini; Andrew F. Olshan; Jane C. Schroeder; Kari E. North; Susan E. Carozza; Karl T. Kelsey; Mei Liu; Terri Rice; John K. Wiencke; Margaret R. Wrensch

doi:10.1159/000108919

DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas

Martha J. Felini, Andrew F. Olshan, Jane C. Schroeder, Kari E. North, Susan E. Carozza, Karl T. Kelsey, Mei Liu, Terri Rice, John K. Wiencke, Margaret R. Wrensch

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71).

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Neuroepidemiology
Volume	29
Issue number	1-2
DOIs	https://doi.org/10.1159/000108919
State	Published - Nov 2007

Keywords

Brain tumors
Case-control
DNA repair polymorphisms
Gliomas
MGMT
XRCC1

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title = "DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas",

abstract = "X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71).",

keywords = "Brain tumors, Case-control, DNA repair polymorphisms, Gliomas, MGMT, XRCC1",

author = "Felini, {Martha J.} and Olshan, {Andrew F.} and Schroeder, {Jane C.} and North, {Kari E.} and Carozza, {Susan E.} and Kelsey, {Karl T.} and Mei Liu and Terri Rice and Wiencke, {John K.} and Wrensch, {Margaret R.}",

year = "2007",

month = nov,

doi = "10.1159/000108919",

language = "English",

volume = "29",

pages = "55--58",

journal = "Neuroepidemiology",

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T1 - DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas

AU - Felini, Martha J.

AU - Olshan, Andrew F.

AU - Schroeder, Jane C.

AU - North, Kari E.

AU - Carozza, Susan E.

AU - Kelsey, Karl T.

AU - Liu, Mei

AU - Rice, Terri

AU - Wiencke, John K.

AU - Wrensch, Margaret R.

PY - 2007/11

Y1 - 2007/11

N2 - X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71).

AB - X-ray cross complementing group 1 (XRCC1) and O6-methylguanine-DNA methyltransferase (MGMT) are pivotal repair genes focused on repairing lesions due to ionizing radiation, alkylating agents, and oxidative DNA damage, risk factors previously linked to gliomas. Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526). We found no evidence of an association between XRCC1 genotypes and glioma. We observed a weak positive association for the MGMT Leu84Phe polymorphism (Leu or Phe/Phe versus Leu/Leu: adjusted OR = 1.26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71).

KW - Brain tumors

KW - Case-control

KW - DNA repair polymorphisms

KW - Gliomas

KW - MGMT

KW - XRCC1

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JO - Neuroepidemiology

JF - Neuroepidemiology

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DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas

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