DNA methylation in endometrial cancer

Meng Hua Tao, Jo L. Freudenheim

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is aberrant DNA methylation. In this review, we review evidence on the role of aberrant DNA methylation, examining changes in relation to endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to endometrial cancer with the emphasis on the role of dietary/lifestyle and environmental factors, as well as opportunities and challenges of DNA methylation in endometrial cancer management and prevention.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalEpigenetics
Volume5
Issue number6
DOIs
StatePublished - Aug 2010

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DNA Methylation
Endometrial Neoplasms
Epigenomics
Life Style
Neoplasms
Carcinogenesis
Gene Expression

Keywords

  • DNA methylation
  • Endometrial cancer
  • Epidemiology

Cite this

Tao, Meng Hua ; Freudenheim, Jo L. / DNA methylation in endometrial cancer. In: Epigenetics. 2010 ; Vol. 5, No. 6. pp. 491-498.
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DNA methylation in endometrial cancer. / Tao, Meng Hua; Freudenheim, Jo L.

In: Epigenetics, Vol. 5, No. 6, 08.2010, p. 491-498.

Research output: Contribution to journalReview article

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AB - Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is aberrant DNA methylation. In this review, we review evidence on the role of aberrant DNA methylation, examining changes in relation to endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to endometrial cancer with the emphasis on the role of dietary/lifestyle and environmental factors, as well as opportunities and challenges of DNA methylation in endometrial cancer management and prevention.

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