DNA double-strand break repair functions defend against parvovirus infection

Thomas J. Tauer, Martin H. Schneiderman, Jamboor K. Vishwanatha, Solon L. Rhode

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single- stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray- induced damage.

Original languageEnglish
Pages (from-to)6446-6449
Number of pages4
JournalJournal of virology
Volume70
Issue number9
DOIs
StatePublished - Sep 1996

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