TY - JOUR
T1 - Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2- 64I) in east Asian and world populations and its implication in AIDS epidemiology
AU - Su, Bing
AU - Jin, Li
AU - Hu, Fang
AU - Xiao, Junhua
AU - Luo, Jingchun
AU - Lu, Daru
AU - Zhang, Weiling
AU - Chu, Jiayou
AU - Du, Ruofu
AU - Geng, Zhencheng
AU - Qiu, Xinfang
AU - Xue, Jinglun
AU - Tan, Jiazhen
AU - O'Brien, Stephen J.
AU - Chakraborty, Ranajit
N1 - Funding Information:
B.S. and R.C. are supported by National Institutes of Health (NIH) grant R01GM41399. L.J. is supported by the TOKTEN project of the United Nations, the Li Foundation, NIH grant R01GM41399, and NIH grant R01GM55759.
PY - 1999
Y1 - 1999
N2 - Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3'A, can delay AIDS onset ≥16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3'A is recessive. SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1-0.2 in most populations. A decreasing cline of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3'A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing cline of the SDF1- 3'A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations.
AB - Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3'A, can delay AIDS onset ≥16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3'A is recessive. SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1-0.2 in most populations. A decreasing cline of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3'A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing cline of the SDF1- 3'A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations.
UR - http://www.scopus.com/inward/record.url?scp=0033365192&partnerID=8YFLogxK
U2 - 10.1086/302568
DO - 10.1086/302568
M3 - Article
C2 - 10486323
AN - SCOPUS:0033365192
SN - 0002-9297
VL - 65
SP - 1047
EP - 1053
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 4
ER -