Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-Δ32) in global populations

Bing Su, Guangyan Sun, Daru Lu, Junhua Xiao, Fang Hu, Ranajit Chakraborty, Ranjan Deka, Li Jin

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection. Mutations at CCR5 (CCR5-Δ32), CCR2 (CCR2-641), and stromal-derived factor SDF1 (SDF1-3'A), a primary ligand for CXCR4, are known to have protective effects against HIV-1 infection and the onset of AIDS symptoms. We studied the three-locus genotype frequency distributions in 70 worldwide populations from a sample of 2341 individuals without any known history of HIV-1 infection and AIDS symptoms. From these data, we estimated the risk of AIDS onset (relative hazard, RH) of each population. This survey shows that the substantial allele frequency differences of each of these mutations translate into an extensive variation in relative hazards for AIDS in worldwide populations. However, no evidence of natural selection against the mutant gene carriers is detected. Finally, the combined three-locus genotype data predict the highest relative hazard (RH) in South-East Asia and Africa where AIDS is known to be more prevalent.

Original languageEnglish
Pages (from-to)975-979
Number of pages5
JournalEuropean Journal of Human Genetics
Volume8
Issue number12
DOIs
StatePublished - 1 Dec 2000

Keywords

  • Chemokine receptors
  • Global populations
  • HIV-1
  • Relative hazard
  • Resistant polymorphisms

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