TY - JOUR
T1 - Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-Δ32) in global populations
AU - Su, Bing
AU - Sun, Guangyan
AU - Lu, Daru
AU - Xiao, Junhua
AU - Hu, Fang
AU - Chakraborty, Ranajit
AU - Deka, Ranjan
AU - Jin, Li
PY - 2000
Y1 - 2000
N2 - Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection. Mutations at CCR5 (CCR5-Δ32), CCR2 (CCR2-641), and stromal-derived factor SDF1 (SDF1-3'A), a primary ligand for CXCR4, are known to have protective effects against HIV-1 infection and the onset of AIDS symptoms. We studied the three-locus genotype frequency distributions in 70 worldwide populations from a sample of 2341 individuals without any known history of HIV-1 infection and AIDS symptoms. From these data, we estimated the risk of AIDS onset (relative hazard, RH) of each population. This survey shows that the substantial allele frequency differences of each of these mutations translate into an extensive variation in relative hazards for AIDS in worldwide populations. However, no evidence of natural selection against the mutant gene carriers is detected. Finally, the combined three-locus genotype data predict the highest relative hazard (RH) in South-East Asia and Africa where AIDS is known to be more prevalent.
AB - Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection. Mutations at CCR5 (CCR5-Δ32), CCR2 (CCR2-641), and stromal-derived factor SDF1 (SDF1-3'A), a primary ligand for CXCR4, are known to have protective effects against HIV-1 infection and the onset of AIDS symptoms. We studied the three-locus genotype frequency distributions in 70 worldwide populations from a sample of 2341 individuals without any known history of HIV-1 infection and AIDS symptoms. From these data, we estimated the risk of AIDS onset (relative hazard, RH) of each population. This survey shows that the substantial allele frequency differences of each of these mutations translate into an extensive variation in relative hazards for AIDS in worldwide populations. However, no evidence of natural selection against the mutant gene carriers is detected. Finally, the combined three-locus genotype data predict the highest relative hazard (RH) in South-East Asia and Africa where AIDS is known to be more prevalent.
KW - Chemokine receptors
KW - Global populations
KW - HIV-1
KW - Relative hazard
KW - Resistant polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=0034507232&partnerID=8YFLogxK
U2 - 10.1038/sj.ejhg.5200568
DO - 10.1038/sj.ejhg.5200568
M3 - Article
C2 - 11175286
AN - SCOPUS:0034507232
SN - 1018-4813
VL - 8
SP - 975
EP - 979
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 12
ER -