Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline

Evidence from calorie restriction intervention

Michael Francis Salvatore, Jennifer Terrebonne, Mark A. Cantu, Tamara R. McInnis, Katy Venable, Parker Kelley, Ella A. Kasanga, Brian Latimer, Catherine L. Owens, Brandon S. Pruett, Yongmei Yu, Robert T. Luedtke, Michael J. Forster, Nathalie Sumien, Donald K. Ingram

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The escalating increase in retirees living beyond their eighth decade brings increased prevalence of aging-related impairments, including locomotor impairment (Parkinsonism) that may affect ~50% of those reaching age 80, but has no confirmed neurobiological mechanism. Lifestyle strategies that attenuate motor decline, and its allied mechanisms, must be identified. Aging studies report little to moderate loss of striatal dopamine (DA) or tyrosine hydroxylase (TH) in nigrostriatal terminals, in contrast to ~70%–80% loss associated with bradykinesia onset in Parkinson’s disease. These studies evaluated the effect of ~6 months 30% calorie restriction (CR) on nigrostriatal DA regulation and aging-related locomotor decline initiated at 12 months of age in Brown-Norway Fischer F1 hybrid rats. The aging-related decline in locomotor activity was prevented by CR. However, striatal DA or TH expression was decreased in the CR group, but increased in substantia nigra versus the ad libitum group or 12-month-old cohort. In a 4- to 6-month-old cohort, pharmacological TH inhibition reduced striatal DA ~30%, comparable with decreases reported in aged rats and the CR group, without affecting locomotor activity. The dissociation of moderate striatal DA reduction from locomotor activity seen in both studies suggests that aging-related decreases in striatal DA are dissociated from locomotor decline.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number1
DOIs
StatePublished - 1 Jan 2018

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Corpus Striatum
Tyrosine 3-Monooxygenase
Dopamine
Locomotion
Hypokinesia
Parkinsonian Disorders
Substantia Nigra
Norway
Parkinson Disease
Life Style
Pharmacology

Keywords

  • Bradykinesia
  • Parkinsonism
  • Parkinson’s disease
  • Striatum
  • Substantia nigra

Cite this

Salvatore, Michael Francis ; Terrebonne, Jennifer ; Cantu, Mark A. ; McInnis, Tamara R. ; Venable, Katy ; Kelley, Parker ; Kasanga, Ella A. ; Latimer, Brian ; Owens, Catherine L. ; Pruett, Brandon S. ; Yu, Yongmei ; Luedtke, Robert T. ; Forster, Michael J. ; Sumien, Nathalie ; Ingram, Donald K. / Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline : Evidence from calorie restriction intervention. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018 ; Vol. 73, No. 1. pp. 11-20.
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abstract = "The escalating increase in retirees living beyond their eighth decade brings increased prevalence of aging-related impairments, including locomotor impairment (Parkinsonism) that may affect ~50{\%} of those reaching age 80, but has no confirmed neurobiological mechanism. Lifestyle strategies that attenuate motor decline, and its allied mechanisms, must be identified. Aging studies report little to moderate loss of striatal dopamine (DA) or tyrosine hydroxylase (TH) in nigrostriatal terminals, in contrast to ~70{\%}–80{\%} loss associated with bradykinesia onset in Parkinson’s disease. These studies evaluated the effect of ~6 months 30{\%} calorie restriction (CR) on nigrostriatal DA regulation and aging-related locomotor decline initiated at 12 months of age in Brown-Norway Fischer F1 hybrid rats. The aging-related decline in locomotor activity was prevented by CR. However, striatal DA or TH expression was decreased in the CR group, but increased in substantia nigra versus the ad libitum group or 12-month-old cohort. In a 4- to 6-month-old cohort, pharmacological TH inhibition reduced striatal DA ~30{\%}, comparable with decreases reported in aged rats and the CR group, without affecting locomotor activity. The dissociation of moderate striatal DA reduction from locomotor activity seen in both studies suggests that aging-related decreases in striatal DA are dissociated from locomotor decline.",
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author = "Salvatore, {Michael Francis} and Jennifer Terrebonne and Cantu, {Mark A.} and McInnis, {Tamara R.} and Katy Venable and Parker Kelley and Kasanga, {Ella A.} and Brian Latimer and Owens, {Catherine L.} and Pruett, {Brandon S.} and Yongmei Yu and Luedtke, {Robert T.} and Forster, {Michael J.} and Nathalie Sumien and Ingram, {Donald K.}",
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Dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline : Evidence from calorie restriction intervention. / Salvatore, Michael Francis; Terrebonne, Jennifer; Cantu, Mark A.; McInnis, Tamara R.; Venable, Katy; Kelley, Parker; Kasanga, Ella A.; Latimer, Brian; Owens, Catherine L.; Pruett, Brandon S.; Yu, Yongmei; Luedtke, Robert T.; Forster, Michael J.; Sumien, Nathalie; Ingram, Donald K.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, No. 1, 01.01.2018, p. 11-20.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - Evidence from calorie restriction intervention

AU - Salvatore, Michael Francis

AU - Terrebonne, Jennifer

AU - Cantu, Mark A.

AU - McInnis, Tamara R.

AU - Venable, Katy

AU - Kelley, Parker

AU - Kasanga, Ella A.

AU - Latimer, Brian

AU - Owens, Catherine L.

AU - Pruett, Brandon S.

AU - Yu, Yongmei

AU - Luedtke, Robert T.

AU - Forster, Michael J.

AU - Sumien, Nathalie

AU - Ingram, Donald K.

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KW - Bradykinesia

KW - Parkinsonism

KW - Parkinson’s disease

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