The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.
|Number of pages||4|
|Journal||International Journal of Clinical Pharmacology and Therapeutics|
|State||Published - 1 Jan 2000|