Abstract
The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.
Original language | English |
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Pages (from-to) | 482-485 |
Number of pages | 4 |
Journal | International Journal of Clinical Pharmacology and Therapeutics |
Volume | 38 |
Issue number | 10 |
DOIs | |
State | Published - 1 Jan 2000 |
Keywords
- Chinese
- Olanzapine
- Pharmacokinetics
- Schizophrenia