Disposition of olanzapine in Chinese schizophrenic patients

H. Y. Lane; H. C. Liu; C. M. Vandenberg; M. H. Su; M. W. Jann; W. H. Chang

doi:10.5414/CPP38482

Disposition of olanzapine in Chinese schizophrenic patients

H. Y. Lane, H. C. Liu, C. M. Vandenberg, M. H. Su, M. W. Jann, W. H. Chang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.

Original language	English
Pages (from-to)	482-485
Number of pages	4
Journal	International Journal of Clinical Pharmacology and Therapeutics
Volume	38
Issue number	10
DOIs	https://doi.org/10.5414/CPP38482
State	Published - 1 Jan 2000

Keywords

Chinese
Olanzapine
Pharmacokinetics
Schizophrenia

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title = "Disposition of olanzapine in Chinese schizophrenic patients",

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keywords = "Chinese, Olanzapine, Pharmacokinetics, Schizophrenia",

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AU - Liu, H. C.

AU - Vandenberg, C. M.

AU - Su, M. H.

AU - Jann, M. W.

AU - Chang, W. H.

PY - 2000/1/1

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N2 - The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.

AB - The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.

KW - Chinese

KW - Olanzapine

KW - Pharmacokinetics

KW - Schizophrenia

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ER -

Disposition of olanzapine in Chinese schizophrenic patients

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