Disposition of olanzapine in Chinese schizophrenic patients

H. Y. Lane, H. C. Liu, C. M. Vandenberg, M. H. Su, M. W. Jann, W. H. Chang

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Abstract

The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (± SD) oral clearance and elimination half-life of olanzapine were 51.5 ± 61.6 l/h and 30.9 ± 4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.

Original languageEnglish
Pages (from-to)482-485
Number of pages4
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume38
Issue number10
DOIs
Publication statusPublished - 1 Jan 2000

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Keywords

  • Chinese
  • Olanzapine
  • Pharmacokinetics
  • Schizophrenia

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