Disposition of Clozapine and Desmethylclozapine in Schizophrenic Patients

Shih‐Ku ‐K Lin, Wen‐Ho ‐H Chang, Ming‐Cheng ‐C Chung, Y. W.Francis Lam, Michael W. Jann

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38 Scopus citations


The disposition of the atypical clozapine and its desmethyl metabolite were evaluated in fourteen male chronic patients. A single 100 mg dose of clozapine was administered and blood sampling performed over the following 72 hours. The mean (SD) oral clearance and half‐life of clozapine were 55.4 (29.7) L/hr and 13.7 (9.9) hours, respectively. The mean (SD) AUC for clozapine and desmethylclozapine was 2389.9 (1406) and 751.1 (622.9) ng ·; hr/mL, respectively. The elimination of the metabolite is rate limited by its formation from cloza‐pine. A wide interpatient variability in clozapine and desmethylclozapine pharmacokinetics was observed. 1994 American College of Clinical Pharmacology

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalThe Journal of Clinical Pharmacology
Issue number4
StatePublished - 1 Jan 1994


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