Discovery of VU0409106: A negative allosteric modulator of mGlu₅ with activity in a mouse model of anxiety

Keyphrases

• Mouse Model 100%
• Metabotropic Glutamate Receptor 5 (mGluR5) 100%
• Negative Allosteric Modulator 100%
• Tool Compound 50%
• MGlu5 NAM 50%
• Allosteric Binding Site 50%
• MGlu 50%
• Anxiolytic 50%
• Marble Burying 50%
• CNS Exposure 50%
• MGlu5 Receptor 50%
• Aryl Ethers 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Allosteric Modulator 100%
• Mouse Model 100%
• Binding Site 50%
• Structure Activity Relationship 50%
• Anxiolytic 50%