Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes

Keyphrases

• Active Compounds 50%
• Antibiotic Therapy 50%
• Antimicrobial Resistance Mechanisms 50%
• Biochemical Tests 50%
• Boronic Acid 50%
• Carbapenemases 50%
• Ceftibuten 50%
• Cephalosporin Antibiotics 50%
• Cephalosporinases 50%
• D-enzyme 100%
• Difficult-to-treat 50%
• Emergency Department Visits 50%
• Enterobacterales 100%
• Extended-spectrum-lactamase 50%
• Gram-negative Bacteria 50%
• Hospital Emergency Department 50%
• Hospitalization 50%
• Lead Optimization 50%
• Lipophilic 50%
• Medicinal Chemistry 50%
• Microbiological Test 50%
• Microbiome Profiling 50%
• Multidrug-resistant 50%
• Oral Bioavailability 50%
• Oral Cephalosporin 50%
• Oral Pharmacokinetics 50%
• Orally Bioavailable 100%
• Outpatient Treatment 50%
• Oxacillinase 50%
• Parenteral Antibiotics 50%
• Prodrug 100%
• Superbugs 50%
• VNRX-7145 100%
• β-lactamase 100%
• β-lactamase Inhibitor 100%

Medicine and Dentistry

• 4alpha Glucanotransferase 100%
• Antibiotic Resistance 20%
• Antibiotic Therapy 20%
• Bioavailability 20%
• Boronic Acid Derivative 20%
• Carbapenemase 20%
• Ceftibuten 20%
• Cephalosporin Derivative 20%
• Emergency Department 20%
• Gram-Negative Bacteria 20%
• Infection 20%
• Outpatient 20%
• Penicillinase 100%
• Pharmacokinetics 20%
• Prodrug 40%

Pharmacology, Toxicology and Pharmaceutical Science

• 4alpha Glucanotransferase 100%
• Antibiotic Therapy 20%
• Antimicrobial Resistance 20%
• Bioavailability 20%
• Boronic Acid Derivative 20%
• Carbapenemase 20%
• Ceftibuten 20%
• Cephalosporin Derivative 20%
• Gram Negative Bacterium 20%
• Infection 20%
• Penicillinase 100%
• Pharmaceutical Chemistry 20%
• Pharmacokinetics 20%
• Prodrug 40%