Discovery of thiophene inhibitors of polo-like kinase

Kyle A. Emmitte, C. Webb Andrews, Jennifer G. Badiang, Ronda G. Davis-Ward, Hamilton D. Dickson, David H. Drewry, Holly K. Emerson, Andrea H. Epperly, Daniel F. Hassler, Victoria B. Knick, Kevin W. Kuntz, Timothy J. Lansing, James A. Linn, Robert A. Mook, Kristen E. Nailor, James M. Salovich, Glenn M. Spehar, Mui Cheung

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

Original languageEnglish
Pages (from-to)1018-1021
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - 1 Feb 2009


  • Benzimidazole
  • Cell-cycle
  • Inhibitor
  • Mitosis
  • Polo-like kinase
  • Thiophene


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