Discovery of thiophene inhibitors of polo-like kinase

Kyle A. Emmitte; C. Webb Andrews; Jennifer G. Badiang; Ronda G. Davis-Ward; Hamilton D. Dickson; David H. Drewry; Holly K. Emerson; Andrea H. Epperly; Daniel F. Hassler; Victoria B. Knick; Kevin W. Kuntz; Timothy J. Lansing; James A. Linn; Robert A. Mook; Kristen E. Nailor; James M. Salovich; Glenn M. Spehar; Mui Cheung

doi:10.1016/j.bmcl.2008.11.041

Discovery of thiophene inhibitors of polo-like kinase

Kyle A. Emmitte, C. Webb Andrews, Jennifer G. Badiang, Ronda G. Davis-Ward, Hamilton D. Dickson, David H. Drewry, Holly K. Emerson, Andrea H. Epperly, Daniel F. Hassler, Victoria B. Knick, Kevin W. Kuntz, Timothy J. Lansing, James A. Linn, Robert A. Mook, Kristen E. Nailor, James M. Salovich, Glenn M. Spehar, Mui Cheung

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Abstract

The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

Original language	English
Pages (from-to)	1018-1021
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2008.11.041
State	Published - 1 Feb 2009

Keywords

Benzimidazole
Cell-cycle
Inhibitor
Mitosis
Polo-like kinase
Thiophene

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10.1016/j.bmcl.2008.11.041

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Emmitte, K. A., Andrews, C. W., Badiang, J. G., Davis-Ward, R. G., Dickson, H. D., Drewry, D. H., Emerson, H. K., Epperly, A. H., Hassler, D. F., Knick, V. B., Kuntz, K. W., Lansing, T. J., Linn, J. A., Mook, R. A., Nailor, K. E., Salovich, J. M., Spehar, G. M., & Cheung, M. (2009). Discovery of thiophene inhibitors of polo-like kinase. Bioorganic and Medicinal Chemistry Letters, 19(3), 1018-1021. https://doi.org/10.1016/j.bmcl.2008.11.041

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title = "Discovery of thiophene inhibitors of polo-like kinase",

abstract = "The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.",

keywords = "Benzimidazole, Cell-cycle, Inhibitor, Mitosis, Polo-like kinase, Thiophene",

author = "Emmitte, {Kyle A.} and Andrews, {C. Webb} and Badiang, {Jennifer G.} and Davis-Ward, {Ronda G.} and Dickson, {Hamilton D.} and Drewry, {David H.} and Emerson, {Holly K.} and Epperly, {Andrea H.} and Hassler, {Daniel F.} and Knick, {Victoria B.} and Kuntz, {Kevin W.} and Lansing, {Timothy J.} and Linn, {James A.} and Mook, {Robert A.} and Nailor, {Kristen E.} and Salovich, {James M.} and Spehar, {Glenn M.} and Mui Cheung",

year = "2009",

month = feb,

day = "1",

doi = "10.1016/j.bmcl.2008.11.041",

language = "English",

volume = "19",

pages = "1018--1021",

journal = "Bioorganic and Medicinal Chemistry Letters",

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number = "3",

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Emmitte, KA, Andrews, CW, Badiang, JG, Davis-Ward, RG, Dickson, HD, Drewry, DH, Emerson, HK, Epperly, AH, Hassler, DF, Knick, VB, Kuntz, KW, Lansing, TJ, Linn, JA, Mook, RA, Nailor, KE, Salovich, JM, Spehar, GM & Cheung, M 2009, 'Discovery of thiophene inhibitors of polo-like kinase', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 3, pp. 1018-1021. https://doi.org/10.1016/j.bmcl.2008.11.041

TY - JOUR

T1 - Discovery of thiophene inhibitors of polo-like kinase

AU - Emmitte, Kyle A.

AU - Andrews, C. Webb

AU - Badiang, Jennifer G.

AU - Davis-Ward, Ronda G.

AU - Dickson, Hamilton D.

AU - Drewry, David H.

AU - Emerson, Holly K.

AU - Epperly, Andrea H.

AU - Hassler, Daniel F.

AU - Knick, Victoria B.

AU - Kuntz, Kevin W.

AU - Lansing, Timothy J.

AU - Linn, James A.

AU - Mook, Robert A.

AU - Nailor, Kristen E.

AU - Salovich, James M.

AU - Spehar, Glenn M.

AU - Cheung, Mui

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

AB - The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

KW - Benzimidazole

KW - Cell-cycle

KW - Inhibitor

KW - Mitosis

KW - Polo-like kinase

KW - Thiophene

UR - http://www.scopus.com/inward/record.url?scp=58649088925&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.11.041

DO - 10.1016/j.bmcl.2008.11.041

M3 - Article

C2 - 19097784

AN - SCOPUS:58649088925

SN - 0960-894X

VL - 19

SP - 1018

EP - 1021

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Discovery of thiophene inhibitors of polo-like kinase

Abstract

Keywords

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