Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Keyphrases

• Metallo-β-lactamase 100%
• Carbapenem Resistance 100%
• β-lactamase 100%
• β-lactamase Inhibitor 100%
• VNRX-5133 100%
• Taniborbactam 100%
• Multidrug-resistant Infection 100%
• Bacterial Infection 33%
• Multidrug-resistant 33%
• Medicinal Chemistry 33%
• Resistance Mechanisms 33%
• Clinical Development 33%
• Microbiome Profiling 33%
• Medical Community 33%
• Difficult-to-treat 33%
• Gram-negative Bacteria 33%
• Lactams 33%
• β-lactam Antibiotics 33%
• Unmet Medical Need 33%
• Narrow Spectrum 33%
• High Mortality Rate 33%
• Carbapenems 33%
• Penicillin 33%
• Active Compounds 33%
• Superbugs 33%
• Structural Biology 33%
• Biochemical Tests 33%
• Cephalosporins 33%
• Carbapenem-resistant Enterobacteriaceae 33%
• Major Resistance 33%
• Global Spread 33%
• Lead Optimization 33%
• Boronic Acid 33%
• Broad-spectrum Inhibitor 33%
• Multidrug-resistant Pseudomonas Aeruginosa (MDRPA) 33%

Medicine and Dentistry

• Bacterial Infection 100%
• Penicillinase 100%
• Serine 100%
• Carbapenem 100%
• Mortality Rate 14%
• In Vitro 14%
• Gram-Negative Bacteria 14%
• Pseudomonas aeruginosa 14%
• Cephalosporin Derivative 14%
• Carbapenem Derivative 14%
• Carbapenem-Resistant Enterobacteriaceae 14%
• Penicillin Derivative 14%
• Boronic Acid Derivative 14%
• Lactam 14%
• β-Lactam antibiotic 14%
• Enzymatic Hydrolysis 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Bacterial Infection 100%
• Serine 100%
• Penicillinase 100%
• Carbapenem 100%
• Pharmaceutical Chemistry 14%
• Mortality Rate 14%
• Gram Negative Bacterium 14%
• Lactam 14%
• Beta Lactam Antibiotic 14%
• Pseudomonas aeruginosa 14%
• Cephalosporin Derivative 14%
• Boronic Acid Derivative 14%
• Carbapenem Resistant Enterobacteriaceae 14%
• Penicillin Derivative 14%
• Carbapenem Derivative 14%