Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Keyphrases

• Metabolism 100%
• Metabotropic Glutamate Receptor 5 (mGluR5) 100%
• Negative Allosteric Modulator 100%
• Aldehyde Oxidase 100%
• Head Group 100%
• Alkoxy 100%
• Allosteric Ligands 50%
• Nonhuman Primate 50%
• Toxicology 50%
• Ether 50%
• MGlu5 NAM 50%
• Cytochrome P450 (CYP450) 50%
• Across Species 50%
• Multiple Domains 50%
• Chemical Optimization 50%
• New Series 50%
• Pyrimidine 50%
• CNS Penetration 50%
• Functional Potency 50%
• Minimum Pharmacophore 50%
• Pyrimidine Moiety 50%

Biochemistry, Genetics and Molecular Biology

• Metabolic Pathway 100%
• Metabotropic Glutamate Receptor 100%
• Metabotropic Receptor 100%
• Aldehyde Oxidase 100%
• Allosteric Regulation 50%
• Pharmacophore 50%
• Metabolite 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Allosteric Modulator 100%
• Metabotropic Receptor 100%
• Aldehyde Oxidase 100%
• Toxicology 50%