Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Ralf Mueller, Eric S. Dawson, Jens Meiler, Alice L. Rodriguez, Brian A. Chauder, Brittney S. Bates, Andrew S. Felts, Jeffrey P. Lamb, Usha N. Menon, Sataywan B. Jadhav, Alexander S. Kane, Carrie K. Jones, Karen J. Gregory, Colleen M. Niswender, P. Jeffrey Conn, Christopher M. Olsen, Danny G. Winder, Kyle A. Emmitte, Craig W. Lindsley

Research output: Contribution to journalArticle

31 Scopus citations
Original languageEnglish
Pages (from-to)406-414
Number of pages9
JournalChemMedChem
Volume7
Issue number3
DOIs
StatePublished - 5 Mar 2012

Keywords

  • Addiction
  • Allosteric modulators
  • Artificial neural networks
  • Metabotropic glutamate receptors
  • Structure-activity relationships

Cite this

Mueller, R., Dawson, E. S., Meiler, J., Rodriguez, A. L., Chauder, B. A., Bates, B. S., Felts, A. S., Lamb, J. P., Menon, U. N., Jadhav, S. B., Kane, A. S., Jones, C. K., Gregory, K. J., Niswender, C. M., Conn, P. J., Olsen, C. M., Winder, D. G., Emmitte, K. A., & Lindsley, C. W. (2012). Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound. ChemMedChem, 7(3), 406-414. https://doi.org/10.1002/cmdc.201100510