Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Ralf Mueller; Eric S. Dawson; Jens Meiler; Alice L. Rodriguez; Brian A. Chauder; Brittney S. Bates; Andrew S. Felts; Jeffrey P. Lamb; Usha N. Menon; Sataywan B. Jadhav; Alexander S. Kane; Carrie K. Jones; Karen J. Gregory; Colleen M. Niswender; P. Jeffrey Conn; Christopher M. Olsen; Danny G. Winder; Kyle A. Emmitte; Craig W. Lindsley

doi:10.1002/cmdc.201100510

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu ₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Ralf Mueller, Eric S. Dawson, Jens Meiler, Alice L. Rodriguez, Brian A. Chauder, Brittney S. Bates, Andrew S. Felts, Jeffrey P. Lamb, Usha N. Menon, Sataywan B. Jadhav, Alexander S. Kane, Carrie K. Jones, Karen J. Gregory, Colleen M. Niswender, P. Jeffrey Conn, Christopher M. Olsen, Danny G. Winder, Kyle A. Emmitte, Craig W. Lindsley

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Original language	English
Pages (from-to)	406-414
Number of pages	9
Journal	ChemMedChem
Volume	7
Issue number	3
DOIs	https://doi.org/10.1002/cmdc.201100510
State	Published - 5 Mar 2012

Keywords

Addiction
Allosteric modulators
Artificial neural networks
Metabotropic glutamate receptors
Structure-activity relationships

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10.1002/cmdc.201100510

Cite this

Mueller, R., Dawson, E. S., Meiler, J., Rodriguez, A. L., Chauder, B. A., Bates, B. S., Felts, A. S., Lamb, J. P., Menon, U. N., Jadhav, S. B., Kane, A. S., Jones, C. K., Gregory, K. J., Niswender, C. M., Conn, P. J., Olsen, C. M., Winder, D. G., Emmitte, K. A., & Lindsley, C. W. (2012). Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu ₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound. ChemMedChem, 7(3), 406-414. https://doi.org/10.1002/cmdc.201100510

@article{56d72cd20a8d40bdaa1ee59bfa1cabb8,

title = "Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound",

keywords = "Addiction, Allosteric modulators, Artificial neural networks, Metabotropic glutamate receptors, Structure-activity relationships",

author = "Ralf Mueller and Dawson, {Eric S.} and Jens Meiler and Rodriguez, {Alice L.} and Chauder, {Brian A.} and Bates, {Brittney S.} and Felts, {Andrew S.} and Lamb, {Jeffrey P.} and Menon, {Usha N.} and Jadhav, {Sataywan B.} and Kane, {Alexander S.} and Jones, {Carrie K.} and Gregory, {Karen J.} and Niswender, {Colleen M.} and Conn, {P. Jeffrey} and Olsen, {Christopher M.} and Winder, {Danny G.} and Emmitte, {Kyle A.} and Lindsley, {Craig W.}",

year = "2012",

month = mar,

day = "5",

doi = "10.1002/cmdc.201100510",

language = "English",

volume = "7",

pages = "406--414",

journal = "ChemMedChem",

issn = "1860-7179",

publisher = "John Wiley and Sons Ltd",

number = "3",

}

Mueller, R, Dawson, ES, Meiler, J, Rodriguez, AL, Chauder, BA, Bates, BS, Felts, AS, Lamb, JP, Menon, UN, Jadhav, SB, Kane, AS, Jones, CK, Gregory, KJ, Niswender, CM, Conn, PJ, Olsen, CM, Winder, DG, Emmitte, KA & Lindsley, CW 2012, 'Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu ₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound', ChemMedChem, vol. 7, no. 3, pp. 406-414. https://doi.org/10.1002/cmdc.201100510

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu ₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound. / Mueller, Ralf; Dawson, Eric S.; Meiler, Jens et al.
In: ChemMedChem, Vol. 7, No. 3, 05.03.2012, p. 406-414.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5)

T2 - From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

AU - Mueller, Ralf

AU - Dawson, Eric S.

AU - Meiler, Jens

AU - Rodriguez, Alice L.

AU - Chauder, Brian A.

AU - Bates, Brittney S.

AU - Felts, Andrew S.

AU - Lamb, Jeffrey P.

AU - Menon, Usha N.

AU - Jadhav, Sataywan B.

AU - Kane, Alexander S.

AU - Jones, Carrie K.

AU - Gregory, Karen J.

AU - Niswender, Colleen M.

AU - Conn, P. Jeffrey

AU - Olsen, Christopher M.

AU - Winder, Danny G.

AU - Emmitte, Kyle A.

AU - Lindsley, Craig W.

PY - 2012/3/5

Y1 - 2012/3/5

KW - Addiction

KW - Allosteric modulators

KW - Artificial neural networks

KW - Metabotropic glutamate receptors

KW - Structure-activity relationships

UR - http://www.scopus.com/inward/record.url?scp=84857732011&partnerID=8YFLogxK

U2 - 10.1002/cmdc.201100510

DO - 10.1002/cmdc.201100510

M3 - Article

C2 - 22267125

AN - SCOPUS:84857732011

SN - 1860-7179

VL - 7

SP - 406

EP - 414

JO - ChemMedChem

JF - ChemMedChem

IS - 3

ER -

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu 5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound

Keywords

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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu ₅): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound