Abstract
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu5). This Letter describes the SAR of this series and the profile of selected compounds in selectivity and radioligand binding assays.
Original language | English |
---|---|
Pages (from-to) | 6623-6626 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 23 |
DOIs | |
State | Published - 1 Dec 2009 |
Keywords
- Glutamate
- Metabotropic glutamate receptor 5
- Negative allosteric modulator
- Non-competitive antagonist
- Quinazoline