A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu5). This Letter describes the SAR of this series and the profile of selected compounds in selectivity and radioligand binding assays.
|Number of pages||4|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|State||Published - 1 Dec 2009|
- Metabotropic glutamate receptor 5
- Negative allosteric modulator
- Non-competitive antagonist