@article{6308809d9ff343679aea2d7dcc043ae3,
title = "Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)",
abstract = "The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an optimized compound is also highlighted.",
keywords = "Cancer, Imidazo[1,2-a]pyridine, Insulin receptor, Insulin-like growth factor-1 receptor, Kinase inhibitor",
author = "Emmitte, {Kyle A.} and Wilson, {Brian J.} and Baum, {Erich W.} and Emerson, {Holly K.} and Kuntz, {Kevin W.} and Nailor, {Kristen E.} and Salovich, {James M.} and Smith, {Stephon C.} and Mui Cheung and Gerding, {Roseanne M.} and Stevens, {Kirk L.} and Uehling, {David E.} and Mook, {Robert A.} and Moorthy, {Ganesh S.} and Dickerson, {Scott H.} and Hassell, {Anne M.} and {Anthony Leesnitzer}, M. and Shewchuk, {Lisa M.} and Arthur Groy and Rowand, {Jason L.} and Kelly Anderson and Atkins, {Charity L.} and Jingsong Yang and Peter Sabbatini and Rakesh Kumar",
note = "Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",
year = "2009",
month = feb,
day = "1",
doi = "10.1016/j.bmcl.2008.11.058",
language = "English",
volume = "19",
pages = "1004--1008",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "3",
}