Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Michael R. Wood, Meredith J. Noetzel, Julie L. Engers, Katrina A. Bollinger, Bruce J. Melancon, James C. Tarr, Changho Han, Mary West, Alison R. Gregro, Atin Lamsal, Sichen Chang, Sonia Ajmera, Emery Smith, Peter Chase, Peter S. Hodder, Michael Bubser, Carrie K. Jones, Corey R. Hopkins, Kyle A. Emmitte, Colleen M. NiswenderMichael W. Wood, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Fingerprint Dive into the research topics of 'Discovery and optimization of a novel series of highly CNS penetrant M<sub>4</sub> PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core'. Together they form a unique fingerprint.

Chemical Compounds

Medicine & Life Sciences