Abstract
Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (1), B (2) and C (3), were discovered from the culture broth of Burkholderia thailandensis E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (4), E (5) and F (6), respectively. Enzyme assays showed that 1-6 are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.
| Original language | English |
|---|---|
| Pages (from-to) | 976-981 |
| Number of pages | 6 |
| Journal | MedChemComm |
| Volume | 3 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2012 |
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Wang, C., Flemming, C. J., & Cheng, Y. Q. (2012). Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264. MedChemComm, 3(8), 976-981. https://doi.org/10.1039/c2md20024d