Abstract
Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (1), B (2) and C (3), were discovered from the culture broth of Burkholderia thailandensis E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (4), E (5) and F (6), respectively. Enzyme assays showed that 1-6 are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.
Original language | English |
---|---|
Pages (from-to) | 976-981 |
Number of pages | 6 |
Journal | MedChemComm |
Volume | 3 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2012 |