Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

Cheng Wang; Creston J. Flemming; Yi Qiang Cheng

doi:10.1039/c2md20024d

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

Cheng Wang, Creston J. Flemming, Yi Qiang Cheng

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (1), B (2) and C (3), were discovered from the culture broth of Burkholderia thailandensis E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (4), E (5) and F (6), respectively. Enzyme assays showed that 1-6 are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.

Original language	English
Pages (from-to)	976-981
Number of pages	6
Journal	MedChemComm
Volume	3
Issue number	8
DOIs	https://doi.org/10.1039/c2md20024d
State	Published - Aug 2012

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Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

Abstract

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