Direction of post-prandial ghrelin response associated with cortisol response, perceived stress and anxiety, and self-reported coping and hunger in obese women

Marjana R. Sarker, Susan Faye Franks, James Caffrey

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The neurobiological mechanisms modulating stress may share common pathways with appetite regulation and consequent obesity. The orexigenic hormone, ghrelin may moderate anxiety and stress-related eating behavior. This study was designed to investigate humoral (ghrelin, cortisol) and psychological/behavioral characteristics (subjective hunger, anxiety, and stress; eating behavior; coping ability) among obese subjects in a fasting state and after eating a standard meal. Subjects included 18 obese but otherwise healthy adult women. Subjects were divided into two groups based on the relative direction of ghrelin response to a standard meal. A meal mediated suppression in serum ghrelin (post/pre. <. .94) was defined as a normal ghrelin response (NG) (n= 9) and failure to suppress (post/pre. >. 1.0) was designated as faulty ghrelin response (FG) (n= 9). Ghrelin and cortisol responses were correlated, r(18). = 0.558, p= .016. FG subjects had lower ratings of coping ability [. t(2,16). = 2.437, p= .027 and higher ratings of hunger cues in the expected direction [. t(2,16). = -2.061, p= .056] compared to NG subjects. Meal mediated declines in subjective hunger were observed for both NG [. t(1,8). = 4.141, p= .003] and FG [. t(1,8). = 2.718, p= .026]. NG also showed declines in subjective anxiety [. t(1,8). = 2.977, p= .018], subjective stress [. t(1,8). = 2.321, p= .049], and cortisol [. t(1,8). = 4.214, p= .003]. In conclusion, changes in ghrelin, cortisol and selected psychological and behavioral indices are closely associated with one another suggesting that ghrelin may influence stress related eating and thus, the consequent observed relationship among stress, mood and obesity.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalBehavioural Brain Research
Volume257
DOIs
StatePublished - 15 Nov 2013

Fingerprint

Ghrelin
Hunger
Meals
Hydrocortisone
Anxiety
Aptitude
Feeding Behavior
Obesity
Eating
Direction compound
Psychology
Appetite Regulation
Cues
Fasting
Hormones

Keywords

  • Anxiety
  • Cortisol
  • Ghrelin
  • Obesity
  • Stress

Cite this

@article{77a25b8e3bed40748c2ffc0bfdb7bc07,
title = "Direction of post-prandial ghrelin response associated with cortisol response, perceived stress and anxiety, and self-reported coping and hunger in obese women",
abstract = "The neurobiological mechanisms modulating stress may share common pathways with appetite regulation and consequent obesity. The orexigenic hormone, ghrelin may moderate anxiety and stress-related eating behavior. This study was designed to investigate humoral (ghrelin, cortisol) and psychological/behavioral characteristics (subjective hunger, anxiety, and stress; eating behavior; coping ability) among obese subjects in a fasting state and after eating a standard meal. Subjects included 18 obese but otherwise healthy adult women. Subjects were divided into two groups based on the relative direction of ghrelin response to a standard meal. A meal mediated suppression in serum ghrelin (post/pre. <. .94) was defined as a normal ghrelin response (NG) (n= 9) and failure to suppress (post/pre. >. 1.0) was designated as faulty ghrelin response (FG) (n= 9). Ghrelin and cortisol responses were correlated, r(18). = 0.558, p= .016. FG subjects had lower ratings of coping ability [. t(2,16). = 2.437, p= .027 and higher ratings of hunger cues in the expected direction [. t(2,16). = -2.061, p= .056] compared to NG subjects. Meal mediated declines in subjective hunger were observed for both NG [. t(1,8). = 4.141, p= .003] and FG [. t(1,8). = 2.718, p= .026]. NG also showed declines in subjective anxiety [. t(1,8). = 2.977, p= .018], subjective stress [. t(1,8). = 2.321, p= .049], and cortisol [. t(1,8). = 4.214, p= .003]. In conclusion, changes in ghrelin, cortisol and selected psychological and behavioral indices are closely associated with one another suggesting that ghrelin may influence stress related eating and thus, the consequent observed relationship among stress, mood and obesity.",
keywords = "Anxiety, Cortisol, Ghrelin, Obesity, Stress",
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T1 - Direction of post-prandial ghrelin response associated with cortisol response, perceived stress and anxiety, and self-reported coping and hunger in obese women

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N2 - The neurobiological mechanisms modulating stress may share common pathways with appetite regulation and consequent obesity. The orexigenic hormone, ghrelin may moderate anxiety and stress-related eating behavior. This study was designed to investigate humoral (ghrelin, cortisol) and psychological/behavioral characteristics (subjective hunger, anxiety, and stress; eating behavior; coping ability) among obese subjects in a fasting state and after eating a standard meal. Subjects included 18 obese but otherwise healthy adult women. Subjects were divided into two groups based on the relative direction of ghrelin response to a standard meal. A meal mediated suppression in serum ghrelin (post/pre. <. .94) was defined as a normal ghrelin response (NG) (n= 9) and failure to suppress (post/pre. >. 1.0) was designated as faulty ghrelin response (FG) (n= 9). Ghrelin and cortisol responses were correlated, r(18). = 0.558, p= .016. FG subjects had lower ratings of coping ability [. t(2,16). = 2.437, p= .027 and higher ratings of hunger cues in the expected direction [. t(2,16). = -2.061, p= .056] compared to NG subjects. Meal mediated declines in subjective hunger were observed for both NG [. t(1,8). = 4.141, p= .003] and FG [. t(1,8). = 2.718, p= .026]. NG also showed declines in subjective anxiety [. t(1,8). = 2.977, p= .018], subjective stress [. t(1,8). = 2.321, p= .049], and cortisol [. t(1,8). = 4.214, p= .003]. In conclusion, changes in ghrelin, cortisol and selected psychological and behavioral indices are closely associated with one another suggesting that ghrelin may influence stress related eating and thus, the consequent observed relationship among stress, mood and obesity.

AB - The neurobiological mechanisms modulating stress may share common pathways with appetite regulation and consequent obesity. The orexigenic hormone, ghrelin may moderate anxiety and stress-related eating behavior. This study was designed to investigate humoral (ghrelin, cortisol) and psychological/behavioral characteristics (subjective hunger, anxiety, and stress; eating behavior; coping ability) among obese subjects in a fasting state and after eating a standard meal. Subjects included 18 obese but otherwise healthy adult women. Subjects were divided into two groups based on the relative direction of ghrelin response to a standard meal. A meal mediated suppression in serum ghrelin (post/pre. <. .94) was defined as a normal ghrelin response (NG) (n= 9) and failure to suppress (post/pre. >. 1.0) was designated as faulty ghrelin response (FG) (n= 9). Ghrelin and cortisol responses were correlated, r(18). = 0.558, p= .016. FG subjects had lower ratings of coping ability [. t(2,16). = 2.437, p= .027 and higher ratings of hunger cues in the expected direction [. t(2,16). = -2.061, p= .056] compared to NG subjects. Meal mediated declines in subjective hunger were observed for both NG [. t(1,8). = 4.141, p= .003] and FG [. t(1,8). = 2.718, p= .026]. NG also showed declines in subjective anxiety [. t(1,8). = 2.977, p= .018], subjective stress [. t(1,8). = 2.321, p= .049], and cortisol [. t(1,8). = 4.214, p= .003]. In conclusion, changes in ghrelin, cortisol and selected psychological and behavioral indices are closely associated with one another suggesting that ghrelin may influence stress related eating and thus, the consequent observed relationship among stress, mood and obesity.

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