Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

Kunlin Jin, Yunjuan Sun, Lin Xie, Alyson Peel, Xiao Ou Mao, Sophie Batteur, David A. Greenberg

Research output: Contribution to journalArticle

459 Scopus citations

Abstract

Pathological processes, including cerebral ischemia, can enhance neurogenesis in the adult brain, but the fate of the newborn neurons that are produced and their role in brain repair are obscure. To determine if ischemia-induced neuronal proliferation is associated with migration of nascent neurons toward ischemic lesions, we mapped the migration of cells labeled by cell proliferation markers and antibodies against neuronal marker proteins, for up to 2 weeks after a 90-min episode of focal cerebral ischemia caused by occlusion of the middle cerebral artery. Doublecortin-immunoreactive cells in the rostral subventricular zone, but not the dentate gyrus, migrated into the ischemic penumbra of the adjacent striatum and, via the rostral migratory stream and lateral cortical stream, into the penumbra of ischemic cortex. These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery.

Original languageEnglish
Pages (from-to)171-189
Number of pages19
JournalMolecular and Cellular Neuroscience
Volume24
Issue number1
DOIs
StatePublished - 1 Sep 2003

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