Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14 and IL-13 genes

David I. Bernstein, Ning Wang, Paloma Campo, Ranajit Chakraborty, Andrew Smith, André Cartier, Louis Philippe Boulet, Jean Luc Malo, Berran Yucesoy, Michael Luster, Susan M. Tarlo, Gurjit K.Khurana Hershey

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Background: Diisocyanate asthma (DA) affects 2% to 10% of exposed workers, yet the pathogenetic mechanisms underlying this disorder remain ill defined. Objective: To determine if specific single nucleotide polymorphisms (SNPs) of interleukin 4 receptor α (ILARA), IL-13, and CD14 promoter genes are associated with DA. Methods: Sixty-two workers with DA confirmed by specific inhalation challenge (SIC) and 75 diisocyanate-exposed, SIC-negative workers were analyzed for SNPs associated with IL4RA, IL-13, and CD14 promoter genes. Results: No associations were found with individual SNPs and DA. When stratified according to specific diisocyanate exposure, a significant association was found between IL4RA (I50V) II and DA among individuals exposed to hexamethylene diisocyanate (HDI) (odds ratio [OR], 3.29; 95% confidence interval [CI], 1.33-8.14; P = .01) only. Similarly, the ILARA (I50V) II and IL-13 (R110Q) RR combination was significantly associated with DA in HDI-exposed workers (OR, 4.13; 95% CI, 1.35-12.68; P = .01), as was the IL4RA (I50V) II and CD14 (C159T) CT genotype combination (OR, 5.2; 95% CI, 1.82-14.88; P = .002) and the triple genotype combination ILARA (I50V) II, IL-13 (R110Q) RR, and CD14 (C159T) CT (OR, 6.4; 95% CI, 1.57-26.12; P = .01). Conclusions: Gene-environmental interactions may contribute to the pathogenesis of DA, and gene-gene interactions may modulate this relationship.

Original languageEnglish
Pages (from-to)800-806
Number of pages7
JournalAnnals of Allergy, Asthma and Immunology
Volume97
Issue number6
DOIs
StatePublished - Dec 2006

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